Block ciphers are widely used in modern cryptography. Substitution boxes (S–boxes) are main elements of these types of ciphers. In this paper we propose a new method to create S–boxes, which is based on application of Cellular Automata (CA). We present the results of testing CA-based S–boxes. These results confirm that CA are able to realize efficiently the Boolean function corresponding to cla...

Bromochloromethane (BCM) is a volatile compound and a by-product of disinfection of water by chlorination. Physiologically based pharmacokinetic (PBPK) models are used in risk assessment applications. An updated PBPK model for BCM is generated and applied to hypotheses testing calibrated using vapor uptake data. The two different metabolic hypotheses examined are (1) a two-pathway model using b...

cellular and molecular anesthesia: from bench to bedside in the current practice of anesthesia, each day, anesthesiologists deal with a great work: they use the cellular mechanisms of drug molecules to induce their desired effects for induction and maintenance of anesthesia to achieve appropriate tolerance of surgery and its pain, modulation of stress response, sedation needed for performing a ...

Transition from proliferation to quiescence brings about extensive changes in cellular behavior and structure. However, the genes that are crucial for establishing and/or maintaining quiescence are largely unknown. The fission yeast Schizosaccharomyces pombe is an excellent model in which to study this problem, because it becomes quiescent under nitrogen starvation. Here, we characterize 610 te...

Topological André-Quillen homology for commutative S-algebras was introduced by Basterra following work of Kriz, and has been intensively studied by several authors. In this paper we discuss it as a homology theory on CW commutative S-algebras and apply it to obtain results on minimal atomic p-local S-algebras which generalise those of Baker and May for p-local spectra and simply connected spac...

objective(s): similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. reprogramming-related transcription factors, also known as yamanaka factors (oct4, sox2, klf4, and c-myc), are also well-known oncogenes promoting cancer initiation, progression, and cellular transformation into cancer stem cells. long non-co...

Introduction Recombinant DNA techniques have revolutionized the field of microbiology. The techniques are quite helpful to analyse and modify various functions of cells. Using recombinant DNA techniques we have succeeded in analysing and modifying the metabolic functions of micro-organisms [ l]. Focusing on the glyoxalase system we have analysed a glycolytic-methylglyoxal cycle and have produce...

The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.

introduction: as an inherited neurodegenerative disease, huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. at this stage of knowledge we are, there is no effective therapeutic strategy for diminishing t...