introduction: acute promyelocytic leukemia treatment revolutionized by new tretamnets. currently number of patinets who undergoe hematopoietic stem cell transplantation decrased so experience with this modality is limited. here we report our experience with stem cell transplantation in acute promyelocytic leukemia patients. design and setting: retrospective, single center methods: between year ...

abstract spinal cord injury (sci) is a devastating condition producing great personal and societal costs and for which there is no effective treatment. stem cell transplantation is a promising therapeutic strategy, though much preclinical and clinical research work remains. here, we briefly describe sci epidemiology, pathophysiology, and transplantation trial in human developments, including te...

stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. however, long-term efficacy and safety of these novel modalities still remain a serious question. hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. fift...

background stem cell transplantation has become as a novel treatment  for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. improved survival of transplant recipients has raised awareness of post-transplant complications. one of these complications is transplant-related osteoporosis. methods  in this manuscript we review prevention methods for transplant-related ...

Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

There is great interest worldwide in discovering and developing a permanent source of tissues which would be capable of generating any cell type and which would avoid the problem of transplant rejection. Stem cells are cells that can specialize into the many different cells found in the human body. The ethical objections concerning stem cells have focused primarily on their source. Human embry...

Objective(s): Neurotrophic factors secreting cells (NTS-SCs) may be a superior cell source for cell-based therapy in neurodegenerative diseases. NTS-SCs are able to secrete some neurotrophic Such as nerve growth factor and glia-derived neurotrophic factor. Our primary aim was to assess transplantation of neurotrophic factor secreting cells derived from human adipose-derived stem cells (hADSCs) ...

background:  renal transplantation is the best choose in the end stage renal disease (esrd), and acute rejection and graft dysfunction remain major challenges in the worldwide, even with the advent of new immunosuppressive drugs. the novel cell-based anti-rejection treatments have been studied by using different stem cell sources. in this study, transplantation of autologous-bone-marrow-derived...