Background: Monocytes are essential components in inflammatory signaling, and their recruitment is crucial the signaling pathway, which directs determines cell adhesion to activated endothelium. A better understanding of correlation between monocyte subsets patients with atherosclerotic disease acute coronary syndrome (ACS) for development more effective therapies prevention treatment cardiovas...

Abstract MicroRNA-21 (miR-21) is upregulated in SLE patients and promotes disease multiple autoimmune mouse models; however, mechanisms by which miR-21 promote autoimmunity are unknown. Here we show that TLR7 overexpressing SLE-prone B6.Sle1b Yaamice deficient (Sle1b YaamiR-21 −/−) resisted development through reduced germinal center (GC) B cell, T follicular helper plasma cell responses. Sle1b...

The elaborate redox network of the cell, comprising events like turnover reactive oxygen species (ROS), sensing, signaling, expression redox-sensitive genes, etc., often orchestrates with other bonafide hormonal signaling pathways through their synergistic or antagonistic action in plant cell. cue generated cells under fluctuating environmental conditions can significantly influence biosyntheti...

Since human beings could travel beyond the earth atmosphere, scientists started to investigate the effect of microgravity on human cells. Microgravity has different effects on normal and cancer cells, but the related mechanisms are not well-known till now. The aim of the present review is to focus on the consequences of exposing the cancer cells to reduced gravity. Some cancer cells organize th...

The ?-selection checkpoint of T cell development tests whether the has recombined its genomic DNA to produce a functional receptor ? (TCR?). Passage through requires nascent TCR? protein mediate signaling pre-TCR complex. In this study, we show that developing cells at establish an immunological synapse in vitro and situ, resembling mature cell. is dependent on two key pathways known be critica...

objective: different signaling pathways have been identified that are involved in the cellular response to opiates. the mitogen-activated protein kinase pathway is one of the most important signaling pathways underlying the neuronal response to opiates. micrornas (mirnas) are considered to be post-transcriptional regulators of gene expression with paramount significance, which plays key roles i...

backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...

low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...