Background: Multiple myeloma (MM) is a malignant plasma cell proliferative disorder with limited immunotherapy treatment because of T cell dysfunction. Objective: To investigate the immunomodulatory function of bone marrow mesenchymal stromal cells (MM-BMSCs) on CD8+ T cells. Methods: Proliferation and cytotoxicity were detected by c...

Studies have presented evidence that besides the well described S phase block, treatment of cancer cell lines with the iron chelator deferrioxamine (DFO) also results in an earlier block in G1 phase. In this article, measurements of cell cycle regulatory proteins define this block at a very specific point in G1. DFO treatment results in markedly decreased cyclin A protein levels. Cyclin E level...

Conditional "cycle-blocked" (cb) mutants of Chlamydomonas reinhardtii have been detected and isolated. These mutants exhibit normal vegetative growth at permissive temperature but are unable to complete a cell cycle (or a specified number of cell cycles) at restrictive temperature. A simple technique has been devised to determine the cell cycle stage in each mutant when the defective gene produ...

Article Patch Based Classification of Cell Painted ER and Cytoplasm using Block Intensity Gradient Pattern Multilayer Perceptron was published on August 1, 2022 in the journal Current Directions Biomedical Engineering (volume 8, issue 2).

The stimuli-responsive nanocomposites were designed as drug delivery nanocarriers. Thanks to promising properties such as large surface area and easy chemical functionalization, the graphene derivatives can be used for the drug delivery applications. For this purpose, in the current work, the poly(L,D-lactide)-block-poly(N-isopropylacrylamide-rand-acrylic acid) grafted from reduced graphene oxi...

Peptide-decorated nanosystems have demonstrated higher stability and improved cellular uptake as compared to bare NPs appear highly promising in diagnostics theranostics of cancer. Herein, we discuss the preparation structural characterization peptide-functionalized silica/PEG NPs, starting from peptide–block copolymers, prepared turn by conjugation peptides block copolymers before NP formation...

H2O2 treatment on U937 cells leads to the block of glycolytic flux and the inactivation of glyceraldehyde-3-phosphate-dehydrogenase by a posttranslational modification (possibly ADP-ribosylation). Glycolysis spontaneously reactivates after 2 h of recovery from oxidative stress; thereafter cells begin to undergo apoptosis. The specific ADP-ribosylation inhibitor 3-aminobenzamide inhibits the str...