BACKGROUND Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease. DESIGN AND METHODS We compared red blood cell aggregation charact...

  SUMMARY Growth factors or colony stimulating factors (CSFs)recently became the subject of headlines around the world. Many published articles in the last few years indicate that the CSFs can correct anemia and pancytopenia of the great majority of patients. Recombinant CSFs are available to the many scientific and therapeutic centers in the U.S.A, Europe and Japan these days. Erythrop oieti...

Sheep red blood cells (SRBCs) rapidly aggregated when injected into the blood (hemolymph) of living silkworms. SRBCs also rapidly aggregated when incubated with hemolymph in vitro. SRBCs did not aggregate when incubated with single hemolymph components, hemocytes and cell-free plasma separated by centrifugation, whereas incubation with the mixture of components induced SRBC aggregation, suggest...

The opportunistic fungal pathogens belonging to the Candida haemulonii complex and phylogenetically related species auris are well-known for causing infections that difficult treat due their multidrug-resistance profiles. is even more worrisome its ability cause outbreaks in healthcare settings. These emerging yeasts produce a wide range of virulence factors facilitate development infectious pr...

The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological prop...

We have studied the effects of two human pancreatic cancer and two human small cell lung cancer cell lines on clotting and platelet aggregation. Both pancreatic lines markedly shortened recalcification times and induced platelet aggregation. The lung cancer lines produced little shortening of recalcification times and no platelet aggregation. The clotting and aggregation activities of the pancr...