The title compound, [Ni(2)(C(12)H(12)N(2)O(4)S(3))(H(2)O)(4)]·2C(3)H(7)NO·3H(2)O, is made up of a centrosymmetric, bimetallic complex containing a 24-membered macrocyclic ring, two dimethyl-formamide and three water solvent mol-ecules. The Ni atom adopts a slightly distorted NiO(6) octahedral geometry arising from two O,O-bidentate ligands and two water molecules. There are inter-molecular O-H⋯...

In the title compound, [Cu(C(13)H(8)N(4)O(3))(H(2)O)]·3H(2)O, the complex molecule, except for the aqua ligand, is essentially planar [r.m.s. deviation = 0.034 (2) Å]. The coordination polyhedron of the Cu(2+) cation is a square-pyramid, with the aqua ligand at the apex. The compound exhibits a three-dimensional structure, which is is stabilized by O-H⋯O and O--H⋯N hydrogen bonds and π-π inter-...

In the title compound, C(15)H(15)N(3)Ox3H(2)O, two of the three water molecules exhibit disorder. The molecular components are linked into a three-dimensional framework by a combination of N-H...O, O-H...N and O-H...O hydrogen bonds.

The absolute configuration of the octa-hedral fac-CoN(3)O(3) title complex, [Co(C(5)H(8)NO(2))(3)]·3H(2)O, has been determined by single-crystal X-ray analysis. A three-dimensional network of hydrogen bonds is observed between the proline carboxyl-ate groups and the three uncoordinated water mol-ecules.

We describe the first cefixime-resistant Neisseria gonorrhoeae strain in Austria that caused treatment failure.It follows the first five cases in Europe of cefixime treatment failure, reported in Norway in 2010 and the United Kingdom in 2011. Effective treatment of gonorrhoea is crucial for public health control and, at present, requires substantially enhanced awareness, more frequent test-of-c...

Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical f...

BACKGROUND The emerging resistance to the extended-spectrum cephalosporins (ESCs) in Neisseria gonorrhoeae together with increasing incidence of gonorrhoea cases in many countries have been global public health concerns. However, in recent years the levels of ESC resistance have decreased in several regions worldwide. We describe the European Gonococcal Antimicrobial Surveillance Programme (Eur...

In this randomized study, a single 800-mg oral dose of cefixime cured 96 of 97 men with uncomplicated gonococcal urethritis, compared with 44 cures of 46 men who received standard therapy with amoxicillin (3 g) plus probenecid (1 g). Both regimens were ineffective against coexistent infection with Chlamydia trachomatis and Ureaplasma urealyticum. Cefixime was well tolerated, and all side effect...

In this study, the direct determination of cefixime as an anti-bacterial agent, in pharmaceutical formulations, urine and human blood plasma was conducted based on spectrophotometric measurements using parallel factor analysis (PARAFAC) and partial least squares (PLS). The calibration set was composed of fourteen solutions in the range of 0.50- 9.00 µg mL-1. PLS models were calculated at each p...