BACKGROUND The standard recommendation for treatment of young, febrile children with urinary tract infection has been hospitalization for intravenous antimicrobials. The availability of potent, oral, third-generation cephalosporins as well as interest in cost containment and avoidance of nosocomial risks prompted evaluation of the safety and efficacy of outpatient therapy. METHODS In a multic...

OBJECTIVE To recommend a cost-effective approach for the management of acute male urethritis in the developing world, based on the findings of a theoretical study. METHODS A model was developed to assess the cost-effectiveness of three urethritis management strategies in a theoretical cohort of 1000 men with urethral syndrome. (1) All patients were treated with cefixime and doxycycline for go...

purpose : to investigate the penetration of cefixime and ciprofloxacin to the rabbit eye on the basis of microbial inhibition of aqueous and vitreous humour after oral administration. methods : in this experimental study, 36 rabbits (72 eyes) were randomly divided into two groups group a consisted of 20 rabbits and group b 16 rabbits. each group was divided into four equal subgroups. the rabbit...

OBJECTIVE To compare the short-term effectiveness of ceftriaxone single dose followed by cefixime with a standard treatment of acute uncomplicated pyelonephritis in women. METHODS An open, prospective, and randomised trial of women with acute uncomplicated pyelonephritis was performed. Group A were given a daily intravenous dose of 1 g ceftriaxone; group B: ceftriaxone 1 g intravenous single ...

OBJECTIVES Decreasing susceptibility of Neisseria gonorrhoeae to fluoroquinolones has been reported in several countries. Knowledge of local N gonorrhoeae susceptibilities to various antimicrobials is important for establishing a rational treatment strategy in each region. METHODS Isolates of N gonorrhoeae from male urethritis patients attending four urological clinics in Hyogo and Osaka pref...

Background and objectives: Rapidly emerging antimicrobial resistance of Neisseria gonorrhoeae isolates to currently recommended antibiotics is a setback for effective treatment and control of disease. This study was carried out to determine the antimicrobial susceptibility profile in the isolates obtained from female sexual workers and male patients attending STI clinics in Hyderabad. Materials...