The carcinoembryonic Ag (CEA) is an attractive target for immunotherapy because of its expression profile and role in tumor progression. To verify the existence of spontaneous anti-CEA CD4+ T cells in lung cancer patients, we first identified CEA sequences forming naturally processed epitopes, and then used the identified epitopes to test their recognition by CD4+ T cells from the patients. We ...

The in vivo localization of radiolabeled heterospecific antibody to carcinoembryonic antigen (CEA) was inves tigated in a human colonie tumor-hamster host model. With the paired-labeled antibody technique, a significant and specific accumulation of goat anti-CEA immunoglobulin G (IgG) was observed in small tumors (<5.0 g) l day after injection. The level of anti-CEA IgG in the tumor sub sequent...

Factors affecting the expression of carcinoembryonic antigen (CEA) at the surface of in vitro human colon carcinoma cells were determined using 125I-labeled antibodies. Binding of specific anti-CEA antibodies resulted in polar redistribution of CEA, followed by endocytosis of most of the CEA-anti-CEA complexes. These processes were temperature and energy dependent. CEA removed from the tumor ce...

Background Previous investigations reported inverse relationship between prostate-specific antigen concentration and body mass index (BMI). These results have been explained by a hemodilution effect among obese men. However, the hemodilution of serum carcinoembryonic antigen (CEA) concentration in obese patients with non-small cell lung cancer (NSCLC) has not been ever reported. Methods Conse...

Consumers initiating returns online may produce secondary packaging, while most of the packages are produced by plastics. The more products returned, plastics used. Existing research indicates that plastic can contribute to micro-plastics pollution environment. As consumer environmental awareness (CEA) improves, and consumers willing pay extra fees change materials from others in order protect ...

Over the last decades, urban agriculture (UA) and controlled environmental (CEA) have been growing in many areas of world to supply fresh food locally provide multiple benefits for sustainable development landscapes. Municipal policies regulatory tools are increasingly employed support UA/CEA minimize practical challenges. However, especially Europe, there is a lack systematic reviews that eval...

antigenic and molecular-weight characteristics which differ from those of CEA obtained from colon tumors (10, 13, 28). An assay specific for breast cancer-derived CEA would have potential usefulness for the early diagnosis and management of human breast carcinoma. However, highly purified extracts of breast CEA suitable for production of specific antisera or radiolabeling have not been prepared...

Carcinoembryonic antigen T cell bispecific antibody (CEA TCB) is a bispecific antibody used to recognize CEA and CD3e via a novel molecular format (2:1) that induces T cell-mediated killing of CEA over-expressing tumors while sparing primary cells with low CEA expression. CEA TCB treatment inhibits tumor growth and generates a highly inflamed tumor microenvironment.

Mice transgenic for the human carcinoembryonic antigen (CEA) gene were prepared for use as a preclinical model for immunotherapy. A 32.6-kb fragment containing the complete human CEA gene and flanking sequences was isolated from a genomic cosmid clone and used to produce transgenic C57BL/6 mice. A homozygous line was established that was designated C57BL/6J-TgN(CEAGe)18FJP. Southern blot analys...

In this report, we have studied the immunogenicity of the nominal antigen, carcinoembryonic antigen (CEA), and that of an anti-idiotype antibody, 3H1, which mimics CEA and can be used as a surrogate for CEA. We have demonstrated that immunization of CEA transgenic mice with bone marrow-derived mature dendritic cells (DC) loaded with antiidiotype 3H1 or CEA could reverse CEA unresponsiveness and...