479 Asthma is one of the most common chronic respiratory diseases worldwide. Despite the regular use of maintenance medications , asthma exacerbations (AEs) can be triggered by various factors. AEs are potentially life-threatening, triggering visits to emergency departments and unscheduled healthcare use in many countries. 1,2 Therefore, AE prediction and prevention are critical in terms of imp...

•Human cord blood-derived CD34-negative HSCs are identified and characterized.•CD133 GPI-80 specific positive/enrichment markers for CD34– HSCs.•CD34–HSCs constitute class of human different from CD34+ reside at the apex HSC hierarchy.•Proposal A revised road map is proposed commitment CB-derived CD34–HSCs. Hematopoietic stem cell (HSC) heterogeneity hierarchy a current topic interest, having m...

•The siRNA micelleplexes were designed for turning “cold” tumors into “hot” ones•Tumor-microenvironment-responsive nanomaterial precise drug delivery•Normalize the tumor vasculature to enhance oxygen-dependent photoimmunotherapy It is highly desirable turn ones improve efficacy of antitumor immunotherapy. Photoimmunotherapy can induce immunogenic cell death (ICD), providing a new path pursue th...