نتایج جستجو برای: cd80

تعداد نتایج: 2396  

2016
Zhuoping Liang Ting Zhang Yi Peng Ting Yang Wenjun Liu Gang Qin

In recent years, studies on the consistency between upper and lower airway inflammation have been receiving more attention; however, the function and mechanism of dendritic cells (DCs) in this context are still not clear. In the present research, we studied the function and mechanism of DCs in the consistency between the upper and lower airway inflammatory responses. CD80, CD86, interferon gamm...

Journal: :Reproductive Biology and Endocrinology 2007
Matthew J Cannon John S Davis Joy L Pate

BACKGROUND Bovine luteal parenchymal cells express class II major histocompatibility complex (MHC) molecules and stimulate class II MHC-dependent activation of T cells in vitro. The ability of a class II MHC-expressing cell type to elicit a response from T cells in vivo is also dependent on expression of costimulatory molecules by the antigen presenting cell and delivery of a costimulatory sign...

Alexey A. Rudko Anna F. Garaeva Densema E. Gomboeva Dmitry Yu. Tsitrikov Elena Yu. Bragina Maxim B. Freidin Nadezhda P. Babushkina

Background: Tuberculosis (TB) is one of the most significant health-care problems worldwide. The host’s genetics play an important role in the development of TB in humans. The disease progresses through several stages, each of which can be under the control of different genes. The precise genes influencing the different stages of the disease are not yet identified. The aim of the current study ...

Journal: :Journal of immunology 2002
Antonella Mencacci Claudia Montagnoli Angela Bacci Elio Cenci Lucia Pitzurra Antonio Spreca Manfred Kopf Arlene H Sharpe Luigina Romani

To find out whether polymorphonuclear neutrophils (PMN), abundantly recruited in disseminated Candida albicans infection, could directly affect the activation of Th cells we addressed the issues as to whether murine PMN, like their human counterparts, express costimulatory molecules and the functional consequence of this expression in terms of antifungal immune resistance. To this purpose, we a...

Journal: :International immunology 2004
Jaewoo Lee Sheila N Sait Meir Wetzler

We asked herein whether functional dendritic-like cells could be generated from t(9;22) acute lymphoblastic leukemia (ALL) blasts. We first determined that the combination of interleukin (IL)-1beta, IL-3, IL-7, tumor necrosis factor-alpha, stem cell factor and CD40 ligand was optimal for generating dendritic-like cells from t(9;22) ALL cell lines. Following 6 days in culture, four of five cell ...

Journal: :International immunology 1997
A Nakajima N Watanabe S Yoshino H Yagita K Okumura M Azuma

The interaction between CD28 and its ligands, CD80 and CD86, is crucial for an optimal activation of antigen-specific T cells. However, the requirement of CD80 or CD86 co-stimulation in Th2 cell differentiation and activation is controversial. Freshly isolated murine CD4+ and CD8+ T cells were incubated with P815 transfectants expressing a similar level of either CD80 or CD86 in the presence of...

Journal: :Journal of virology 2006
Shinichiro Fuse Joshua J Obar Sarah Bellfy Erica K Leung Weijun Zhang Edward J Usherwood

The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells serve as an important costimulatory signal in the activation of T cells. Although the simplistic two-signal hypothesis has been challenged in recent years by the identification of different costimulators, this classical pathway has been shown to significantly impact antiviral humoral and cellular immune respo...

Journal: :Journal of immunology 2002
Thomas J Lang Phuong Nguyen Robert Peach William C Gause Charles S Via

To address whether a functional dichotomy exists between CD80 and CD86 in naive T cell activation in vivo, we administered anti-CD80 or CD86 blocking mAb alone or in combination to mice with parent-into-F(1) graft-vs-host disease (GVHD). In this model, the injection of naive parental T cells into unirradiated F(1) mice results in either a Th1 cytokine-driven, cell-mediated immune response (acut...

Journal: :Journal of immunology 2015
Ruishu Deng Kaniel Cassady Xiaofan Li Sheng Yao Mingfeng Zhang Jeremy Racine Jeffrey Lin Lieping Chen Defu Zeng

Interactions of B7H1 (programmed death ligand 1 [PD-L1]) with its two ligands, PD-1 and CD80, on T cells play a pivotal role in controlling T cell activation, proliferation, anergy, and apoptosis. However, the interactions between the two pathways remain unknown. Using an alloimmune response model of graft-versus-host disease (GVHD), we report in this study that: 1) Comparison of proliferation ...

Journal: :Journal of immunology 2005
Karin Loser Andrea Scherer Mathias B W Krummen Georg Varga Tetsuya Higuchi Thomas Schwarz Arlene H Sharpe Stephan Grabbe Jeffrey A Bluestone Stefan Beissert

Although previous studies have shown that altered B7 costimulation plays a critical role in UV irradiation-induced regulation of immunity, the individual roles of the B7 receptors (CD28 and CTLA-4) or the B7 family members (CD80 and CD86) have not been explored. Thus, we investigated CTLA-4 signaling during photocarcinogenesis of chronically UV-B-exposed mice using an antagonistic anti-CTLA-4 A...

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