نتایج جستجو برای: cd44 سیکل سل

تعداد نتایج: 14607  

2016
Anne Pink Marianna Školnaja Taavi Päll Andres Valkna

CD44 transmembrane glycoprotein is involved in angiogenesis, but it is not clear whether CD44 functions as a pro­ or antiangiogenic molecule. Here, we assess the role of CD44 in angiogenesis and endothelial proliferation by using Cd44­null mice and CD44 silencing in human endothelial cells. We demonstrate that angiogenesis is increased in Cd44­null mice c...

2015
Zhiqun Shang Qiliang Cai Minghao Zhang Shimiao Zhu Yuan Ma Libin Sun Ning Jiang Jing Tian Xiaodan Niu Jiatong Chen Yinghao Sun Yuanjie Niu

Epithelial-mesenchymal transition (EMT) has been linked to cancer stem-like (CD44+) cell in the prostate cancer (PCa) metastasis. However, the molecular mechanism remains elusive. Here, we found EMT contributed to metastasis in PCa patients failed in androgen deprivation therapy (ADT). Castration TRAMP model also proved PCa treated with ADT promoted EMT with increased CD44+ stem-like cells. Swi...

2015
Hanxiao Xu Yijun Tian Xun Yuan Hua Wu Qian Liu Richard G Pestell Kongming Wu

CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially identified as a receptor for hyaluronan that participates in both physiological and pathological processes. CD44 is found to be closely linked to the development of various solid tumors. Molecular studies have revealed that high CD44 expression was correlated with the phenotypes of cancer stem cells and epith...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1995
S A Cannistra B DeFranzo J Niloff C Ottensmeir

We have previously shown that CD44 partly mediates ovarian cancer cell attachment to peritoneal mesothelium through recognition of mesothelial-associated hyaluronate. CD44 is a major receptor for hyaluronate and exists as a standard 90-180-kDa form (CD44H), as well as several higher molecular mass variant forms produced by alternative splicing. To determine whether functional differences exist ...

Journal: :The Journal of Cell Biology 1995
K L Bennett D G Jackson J C Simon E Tanczos R Peach B Modrell I Stamenkovic G Plowman A Aruffo

Glycosaminoglycan-modified isoforms of CD44 have been implicated in growth factor presentation at sites of inflammation. In the present study we show that COS cell transfectants expressing CD44 isoforms containing the alternatively spliced exon V3 are modified with heparan sulfate (HS). Binding studies with three HS-binding growth factors, basic-fibroblast growth factor (b-FGF), heparin binding...

Journal: :The Journal of Experimental Medicine 1994
J Lesley N Howes A Perschl R Hyman

Though CD44 functions as a cell surface receptor for hyaluronan (HA) in some cell lines, most normal hematopoietic cells expressing CD44 do not bind HA. Certain CD44-specific monoclonal antibodies (mAbs) can rapidly induce CD44-mediated HA binding in normal murine T cells. This observation suggests that in vivo mechanisms may exist for activating the HA receptor function of CD44 on normal T cel...

Journal: :International journal of molecular medicine 2009
Christian Albrecht Werner Schlegel Peter Eckl Tamara Jagersberger Kambis Sadeghi Angelika Berger Vilmos Vécsei Stefan Marlovits

The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular cartilage were cultured as a monolayer for up to 36 days and were seeded on two dif...

Journal: :Blood 2002
Sophia Khaldoyanidi Svetlana Karakhanova Jonathan Sleeman Peter Herrlich Helmut Ponta

Hemopoiesis is regulated by the complex interplay between the bone marrow microenvironment and hemopoietic stem cells and progenitors. The local production of cytokines plays a critical role in this process. Using long-term bone marrow cultures, we show here that monoclonal antibodies directed against the CD44 v4 and CD44 v6 epitopes stimulate myelopoiesis (CD44 v4 and CD44 v6) and lymphopoiesi...

Journal: :Cancer research 2010
Yin Xu Ivan Stamenkovic Qin Yu

Glioblastoma multiforme (GBM) is the most aggressive brain tumor that, by virtue of its resistance to chemotherapy and radiotherapy, is currently incurable. Identification of molecules whose targeting may eliminate GBM cells and/or sensitize glioblastoma cells to cytotoxic drugs is therefore urgently needed. CD44 is a major cell surface hyaluronan receptor and cancer stem cell marker that has b...

Journal: :The Journal of clinical investigation 2003
Shigeki Katoh Nobuhiro Matsumoto Kumiko Kawakita Akira Tominaga Paul W Kincade Shigeru Matsukura

Previous studies established that IL-5-producing CD4(+) T cells play a pivotal role in allergic respiratory inflammation. It was also reported that CD4(+) T cells express higher levels of CD44 in the airway than in peripheral blood of patients with allergic respiratory diseases. We have used experimental pulmonary eosinophilia induced in mice by Ascaris suum (Asc) extract to investigate the rol...

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