This review summarizes recent progress in understanding the pathogenesis of IgG4-related disease (IgG4-RD), with a focus on fibrosis. Several studies reported that CD4+ T cells cytotoxic activity promoted by secretion granzyme and perforin, (CD4+CTLs), disease-specific activated B cells, infiltrated inflamed tissues cooperated to induce tissue fibrosis autoimmune fibrotic diseases such as IgG4-...

background : aids is acquired by infection with hiv (human immuno-deficiency virus). it leaves the host susceptible to malignant and unusual infections especially opportunistic ones. most of aids patients infected with opportunistic parasitic infections die because of chronic diarrhea and deaths due to cryptosporidium diarrhea in aids patients are considerable in the recent two decades. the aim...

The cancer-immune interplay and its role on the evolution of NSCLC might be disclosed through detection local systemic cues. Aim: To determine whether peripheral blood (PB) immune profiles may mirror clinically relevant tumor microenvironmental (TIME) features in resected patients. Tissue PB samples were prospectively collected at surgery from 80 consecutive stage I-IIIA cases. immunohistochemi...

lymphocyte cd4 + count, a standard laboratory test for staging of hiv infection, is expensive and unavailable in resource-restricted countries. total lymphocyte count (tlc) and hemoglobin (hb) are recommended as simple & inexpensive surrogates. the aim of this study was to assess the correlation, sensitivity and predictive power of these parameters as substitutes for cd 4 count. one hundred hiv...

Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...

The study included 24 patients, which formed the baseline group — 12 patients with pulmonary tuberculosis in combination COVID-19 infection and control tuberculosis. There were studied leukocyte formula, content of CD3, CD4, CD8 lymphocytes, NO2-+NO3- total its metabolites. obtained results showed that there is a pronounced decrease lymphocytes an unexpressed shift formula to left. lymphocyte d...