نتایج جستجو برای: cd3

تعداد نتایج: 11176  

Journal: :Cancer research 1990
D D Schoof C M Selleck A F Massaro S E Jung T J Eberlein

We have used high concentrations of recombinant-methionyl human interleukin 2 (rIL-2) for the initial growth and expansion of human tumor-infiltrating lymphocytes (TIL). Early in the life of the TIL bulk culture, cytotoxicity was non-major histocompatibility complex restricted. Under these culture conditions antitumor cytotoxicity was observed to decline with increasing age of the bulk culture....

Journal: :The Journal of pharmacology and experimental therapeutics 1997
A M Evans A Mancinelli A Longo

Propionyl-L-carnitine (PLC) is an ester of L-carnitine (LC) under evaluation for the treatment of cardiovascular disorders. The renal disposition of PLC was studied in the isolated perfused rat kidney with deuterium-labeled derivative (PLC-CD3). Kidneys of male Sprague-Dawley rats were perfused at initial PLC-CD3 concentrations of 10 (n = 4) and 200 microM (n = 5). High-performance liquid chrom...

Journal: :The Journal of Experimental Medicine 1987
L L Lanier N A Federspiel J J Ruitenberg J H Phillips J P Allison D Littman A Weiss

IL-2-dependent cell lines were established from normal peripheral blood T lymphocytes that express neither CD4 nor CD8 differentiation antigens. CD3+,4-,8- cell lines from 15 different donors failed to react with WT31, an mAb directed against the T cell antigen receptor alpha/beta heterodimer. Anti-Leu-4 mAb was used to isolate the CD3/T cell antigen receptor complex from 125I-labeled CD3+,4-,8...

2016
Kerstin H. Mair Maria Stadler Stephanie C. Talker Hilde Forberg Anne K. Storset Andrea Müllebner J. Catharina Duvigneau Sabine E. Hammer Armin Saalmüller Wilhelm Gerner

The CD3(-)NKp46(+) phenotype is frequently used for the identification of natural killer (NK) cells in various mammalian species. Recently, NKp46 expression was analyzed in more detail in swine. It could be shown that besides CD3(-)NKp46(+) lymphocytes, a small but distinct population of CD3(+)NKp46(+) cells exists. In this study, we report low frequencies of CD3(+)NKp46(+) lymphocytes in blood...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Sophie V Pageon Thibault Tabarin Yui Yamamoto Yuanqing Ma Philip R Nicovich John S Bridgeman André Cohnen Carola Benzing Yijun Gao Michael D Crowther Katie Tungatt Garry Dolton Andrew K Sewell David A Price Oreste Acuto Robert G Parton J Justin Gooding Jérémie Rossy Jamie Rossjohn Katharina Gaus

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How the extracellular antigen recognition event leads to intracellular phosphorylation remains unclear. Here, we used single-molecule localizat...

Journal: :The Journal of Experimental Medicine 1992
J D Dasgupta C Granja B Druker L L Lin E J Yunis V Relias

Recently, we and others have reported tyrosine phosphorylation of phospholipase C-gamma 1 (PLC gamma 1) enzyme after CD3 activation of T cells, and have proposed that PLC gamma 1 mediates signal transduction through the T cell receptor (TCR/CD3). Here, using immunoblotting and immune complex PLC assays, we show that CD3 stimulation of Jurkat cells induces the association of PLC gamma 1 enzyme w...

Journal: :The Journal of Cell Biology 1996
J Dietrich A Neisig X Hou A M Wegener M Gajhede C Geisler

The T cell receptor (TCR) consists of the Ti alpha beta heterodimer and the associated CD3 gamma delta epsilon and zeta 2 chains. The structural relationships between the subunits of the TCR complex are still not fully known. In this study we examined the role of the extracellular (EC), transmembrane (TM), and cytoplasmic (CY) domain of CD3 gamma in assembly and cell surface expression of the c...

Journal: :PLoS ONE 2009
Liyun Zhong Gucheng Zeng Xiaoxu Lu Richard C. Wang Guangming Gong Lin Yan Dan Huang Zheng W. Chen

Direct molecular imaging of nano-spatial relationship between T cell receptor (TCR)/CD3 and CD4 or CD8 co-receptor before and after activation of a primary T cell has not been reported. We have recently innovated application of near-field scanning optical microscopy (NSOM) and immune-labeling quantum dots (QD) to image Ag-specific TCR response during in vivo clonal expansion, and now up-graded ...

Journal: :Acta Marisiensis 2021

Abstract Objective: In vitro cytokine production by peripheral blood mononuclear cells (PBMCs) is an important and reliable measure of immunocompetence. PBMC can be stimulated directly after isolation or frozen for later use. However, cryopreservation may affect cell recovery, viability functionality. This study aims to investigate synthesis in ex-vivo fresh cryopreserved CD4+ CD4- T cells. Met...

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