BACKGROUND AND AIMS Presence of serum antibodies against Mycobacterium avium paratuberculosis (MAP) in Crohn's Disease (CD) as a disease characteristic remains controversial. In the present work, we assessed antibody reactivity of serum and intestinal fluid against four distinct MAP-antigens, including the recently identified MAP-specific lipopentapeptide (L5P). METHODS Immunoglobulin concent...

BACKGROUND Abnormal handling of E. coli by lamina propria (LP) macrophages may contribute to Crohn's disease (CD) pathogenesis. We aimed to determine LP macrophage phenotypes in CD, ulcerative colitis (UC) and healthy controls (HC), and in CD, to compare macrophage phenotypes according to E. coli carriage. METHODS Mucosal biopsies were taken from 35 patients with CD, 9 with UC and 18 HCs. Las...

Aims We aimed to perform a meta-analysis of the predictive capacity of fecal calprotectin (FC) in activity and relapse of Crohn's disease (CD). Materials and methods MEDLINE, EMBASE, and the Cochrane Library databases were searched systematically. Pooled sensitivity, specificity, and other diagnostic indices were evaluated. Results A total of 1,252 CD patients from 18 different studies were...

The cadmium (Cd), a heavy metal, causes toxicity, which leads to hampering the growth and development of the plant. The molecular and biochemical approaches were used for the investigation of antioxidant system response and genotoxicity in date palm (Phoenix dactylifera L.) cv. Sagai in pot experiment having Cd. The root length was more affected than the shoot length as more accumulation of Cd ...

BACKGROUND The immune-mediated enteropathy, celiac disease (CD), and gluten sensitivity (GS) are two distinct clinical conditions that are both triggered by the ingestion of wheat gliadin. CD, but not GS, is associated with and possibly mediated by an autoimmune process. Recent studies show that gliadin may induce the activation of IL-17-producing T cells and that IL-17 expression in the CD muc...

AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker. METHODS Serum IL9 as well as other cytokines (IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease (CD) and 74 with ulcerative colitis (UC) and in 122 apparently healthy controls. The...

Breast carcinoma is one of the most frequently occurring cancers among women with million cases. cancer primary cause death in around world. It major concerns public health due to its high occurrence and growing tendency. This complex functional structure develops from a highly modified apocrine sweat gland female, but remains rudimentary male. embryological into two lines along milk extending ...

s of the 4th Congress of ECCO the European Crohn’s and Colitis Organisation S113 families into Swedish and non-Swedish families in order to investigate for a population specific effect of the CLDN2 marker in the family-based approach. Only Swedish families preserved a significant association between the CLDN2 marker and CD (allelic OR = 2.95, 95% 0.99 8.83, p = 0.033). No associations were foun...