نتایج جستجو برای: ccl22

تعداد نتایج: 1448  

Journal: :American journal of reproductive immunology 2015
Martina S Abelius Camilla Janefjord Jan Ernerudh Göran Berg Leif Matthiesen Karel Duchén Lennart J Nilsson Maria C Jenmalm

PROBLEM How maternal allergy affects the systemic and local immunological environment during pregnancy and the immune development of the offspring is unclear. METHOD OF STUDY Expression of 40 genes was quantified by PCR arrays in placenta, peripheral blood mononuclear cells (PBMC), and cord blood mononuclear cells (CBMC) from 7 allergic and 12 non-allergic women and their offspring. RESULTS...

Journal: :European journal of immunology 2011
Geneviève Paulissen Natacha Rocks Maud M Guéders Denis Bedoret Céline Crahay Florence Quesada-Calvo Jonathan Hacha Sandrine Bekaert Christophe Desmet Jean-Michel Foidart Fabrice Bureau Agnès Noel Didier D Cataldo

Asthma is a complex disease linked to various pathophysiological events including the activity of proteinases. The multifunctional A disintegrin and metalloproteinases (ADAMs) displaying the ability to cleave membrane-bound mediators or cytokines appear to be key mediators in various inflammatory processes. In the present study, we investigated ADAM-8 expression and production in a mouse model ...

Journal: :International immunology 2008
Zijin Guo Myoung Ho Jang Kazuhiro Otani Zhongbin Bai Eiji Umemoto Masanori Matsumoto Mika Nishiyama Mikako Yamasaki Satoshi Ueha Kouji Matsushima Takako Hirata Masayuki Miyasaka

CD4(+)CD25(+) regulatory T cells (Tregs) have been implicated in the suppression of pathogenic responses to both self- and non-self-antigens in the intestine. However, their precise properties and functions in the gut, as well as the molecular basis of their recruitment to the gut, are poorly understood. Here, we found that most of the CD4(+)CD25(+) T cells in the small intestinal lamina propri...

Journal: :Infection and immunity 2008
Tobias Traeger Wolfram Kessler Volker Assfalg Katharina Cziupka Pia Koerner Constanze Dassow Katrin Breitbach Marlene Mikulcak Ivo Steinmetz Klaus Pfeffer Claus-Dieter Heidecke Stefan Maier

CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4(-/-)) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4(-/-) mice with a C57BL/6 background, this study describes for the first time the role of CC...

Journal: :Investigative ophthalmology & visual science 2010
Lukas J A G Ricker Aize Kijlstra Wilco de Jager Albert T A Liem Fred Hendrikse Ellen C La Heij

PURPOSE Interleukin (IL)-6, a multifunctional cytokine with regulatory functions in wound healing, and several chemokines have been implicated in the pathogenesis of proliferative vitreoretinopathy (PVR) after rhegmatogenous retinal detachment (RRD). The exact role of these chemokines, their correlation with IL-6 after primary RRD, and their association with the future development of PVR are no...

Journal: :Journal of immunology 2004
Patricia C Fulkerson Nives Zimmermann Lynn M Hassman Fred D Finkelman Marc E Rothenberg

The expression of distinct chemokines within the asthmatic lung suggests that specific regulatory mechanisms may mediate various stages of asthmatic disease. Global transcript expression profiling was used to define the spectrum and kinetics of chemokine involvement in an experimental murine model of asthma. Seventeen chemokines were induced in the lungs of allergen-inoculated mice, as compared...

2014
Edwin Lok Amy S. Chung Kenneth D. Swanson Eric T. Wong

The aggressiveness of melanoma is believed to be correlated with tumor-stroma-associated immune cells. Cytokines and chemokines act to recruit and then modulate the activities of these cells, ultimately affecting disease progression. Because melanoma frequently metastasizes to the brain, we asked whether global differences in immunokine profiles could be detected in the cerebrospinal fluid (CSF...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Sayed F Abdelwahab Fiorenza Cocchi Kenneth C Bagley Roberta Kamin-Lewis Robert C Gallo Anthony DeVico George K Lewis

CD4+ T cells are required for immunity against many viral infections, including HIV-1 where a positive correlation has been observed between strong recall responses and low HIV-1 viral loads. Some HIV-1-specific CD4+ T cells are preferentially infected with HIV-1, whereas others escape infection by unknown mechanisms. One possibility is that some CD4+ T cells are protected from infection by the...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Anh Thu Nguyen Hoang Puran Chen Julius Juarez Patty Sachamitr Bo Billing Lidija Bosnjak Barbro Dahlén Mark Coles Mattias Svensson

In lung tissue, dendritic cells (DC) are found in close association with the epithelial cell layer, and there is evidence of DC regulation by the epithelium; that epithelial dysfunction leads to overzealous immune cell activation. However, dissecting basic mechanisms of DC interactions with epithelial cells in human tissue is difficult. Here, we describe a method to generate a three-dimensional...

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