The main aim of this study was to obtain the Crimean-Congo hemorrhagic fever virus (CCHFV) glycoprotein, through either stable transgenic plants or using a transient expression system, and determine the yield, quality and finally the immunogenicity of the plant-made CCHFV glycoprotein in a mouse model. We designed and synthesized a codon-optimized G1/G2 gene from the G1 and G2 parts of the CCHF...

Introduction: Crimean-Congo Hemorrhagic Fever (CCHF) is a zoonotic viral infection transmitted mainly via CCHF virus-infected ticks between vertebrate hosts. The disease occurs in almost all provinces of Iran. This study investigated the CCHFV infection in hard ticks collected from livestock in the Sistan region of Sistan and Baluchestan Province, southeast of Iran. Methods: In this study, tick...

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne that causes silent infections of livestock animals and severe illness in humans. Circulation CCHFV among within geographic region can be detected by the presence antibodies to virus. In Kosovo, human cases have occurred most frequently Malisheve region, but not been seen Vushtrri. The study was carried out 2018 Vushtrri determine pre...

BACKGROUND & OBJECTIVES Zoonotic diseases are well recognised threat to public health globally. The information of regional prevalence and associated risk factors allow the national programmes to determine and frame better strategies for their control, as they also provide the actual status of zoonosis in the region. The aim of this study was to determine the seroprevalence of West Nile virus (...

Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging tick-borne virus of the Bunyaviridae family that is responsible for a fatal human disease for which preventative or therapeutic measures do not exist. We solved the crystal structure of the CCHFV strain Baghdad-12 nucleocapsid protein (N), a potential therapeutic target, at a resolution of 2.1 Å. N comprises a large globular domain co...

Hyalomma marginatum and rufipes are important vectors of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in North Africa Southern Europe. They occasionally also reported from Central Western Europe where they likely introduced their natural range by migratory birds. In this study, we report findings molecular identification adults one nymph H. rufipes, primarily horses different regions the Czech...

To the Editor: Crimean Congo hemorrhagic fever, a tick-borne illness caused by Crimean Congo hemorrhagic fever virus (CCHFV), is endemic to Africa, the Balkans, the Middle East, and parts of Asia. The hard ticks (Ixodidae), especially those of the genus Hyalomma, serve as reservoirs and vectors for CCHFV, and a variety of animals, such as cattle, sheep, and camels, are considered amplifying hos...

The Bunyaviridae family is the largest virus family consisting of more than 350 viruses. Despite the increasing knowledge regarding the biology of members of this family, little is known about Crimean-Congo hemorrhagic fever virus (CCHFV), a virus classified within the Nairovirus genus and the causative agent of a severe hemorrhagic fever in humans with high mortality. The virus is transmitted ...

Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral disease, widely distributed in different regions of the world. The fever is caused by the CCHF virus (CCHFV), which belongs to the Nairovirus genus and Bunyaviridae family. The virus is clustered in seven genotypes, which are Africa-1, Africa-2, Africa-3, Europe-1, Europe-2, Asia-1 and Asia-2. The virus is highly pathogenic in natur...

Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are common representatives of viral hemorrhagic fevers still often neglected in some parts of the world. Infection with Dobrava or Puumala virus (HFRS) and Crimean-Congo hemorrhagic fever virus (CCHFV) can result in a mild, nonspecific febrile illness or as a severe disease with hemorrhaging and high fatalit...