The expression pattern and functional interaction of proangiogenic factors in human cholangiocellular carcinoma (CCC) have not been fully defined. We therefore investigated the expression of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-beta 1 as well as their respective receptors in human CCC tumor samples and further analyzed their functional interaction in vi...

OBJECTIVE The objective of this study was to evaluate the antitumor effects of lurbinectedin as a single agent or in combination with existing anticancer agents for clear cell carcinoma (CCC) of the ovary, which is regarded as an aggressive, chemoresistant, histological subtype. METHODS Using human ovarian CCC cell lines, the antitumor effects of lurbinectedin, SN-38, doxorubicin, cisplatin, ...

BACKGROUND AND OBJECTIVES Coronary collateral circulation (CCC) has been attributed as inborn bypass mechanisms supporting ischemic myocardium. Various factors have been postulated in CCC. Whole blood viscosity (WBV) has been an underappreciated entity despite close relationships between multiple cardiovascular diseases. WBV can be calculated with a validated equation from hematocrit and total ...

BACKGROUND We aimed to investigate the clinical features associated with development of coronary collateral circulation (CCC) in patients with acute non-ST-elevation myocardial infarction (NSTEMI) and to develop a scoring model for predicting poor collateralization at hospital admission. METHODS The study enrolled 224 consecutive patients with NSTEMI admitted to our coronary care unit. Patien...

The aim of the present investigation was to determine the effect of plant growth regulators viz., kinetin, chlorocholine chloride (CCC) and salicylic acid (SA) on achene yield and oil quality of safflower (Carthamus tinctorius L.) cv. Thori pertaining to biodiesel production. The growth regulators were applied at 10M as foliar spray during flowering (140 days after sowing). Kinetin was highly e...

In this paper, we study the following Chromatic Cone Clustering (CCC) problem: Given n point-sets with each containing k points in the first quadrant of the d-dimensional space R, find k cones apexed at the origin such that each cone contains at least one distinct point (i.e., different from other cones) from every point-set and the total size of the k cones is minimized, where the size of a co...

The goal of this study was to examine the role of mTOR complex 2 (mTORC2) as a therapeutic target in ovarian clear cell carcinoma (CCC), which is regarded as an aggressive, chemoresistant histologic subtype. Using tissue microarrays of 98 primary ovarian cancers [52 CCCs and 46 serous adenocarcinomas (SAC)], activation of mTORC2 was assessed by immunohistochemistry. Then, the growth-inhibitory ...

The goal of this study was to examine the role of mTOR complex 2 (mTORC2) as a therapeutic target in ovarian clear cell carcinoma (CCC), which is regarded as an aggressive, chemoresistant histologic subtype. Using tissue microarrays of 98 primary ovarian cancers [52 CCCs and 46 serous adenocarcinomas (SAC)], activationofmTORC2wasassessedby immunohistochemistry.Then, thegrowth-inhibitory effecto...

Let I be an ideal of subsets of a Polish space X, containing all singletons and possessing a Borel basis. Assuming that I does not satisfy ccc, we consider the following conditions (B), (M) and (D). Condition (B) states that there is a disjoint family F ⊆ P (X) of size c, consisting of Borel sets which are not in I . Condition (M) states that there is a Borel function f : X → X with f[{x}] / ∈ ...

OBJECTIVES To compare the clinicopathologic features and prognosis of Chinese patients with ovarian clear cell carcinoma (CCC) and serous carcinoma (SC). METHODS A retrospective cohort study was designed to investigate the clinicopathologic characteristic and prognosis of patients with CCC and SC who were diagnosed and treated in in a tertiary referral center (Peking Union Medical College Hos...