نتایج جستجو برای: catsper
تعداد نتایج: 168 فیلتر نتایج به سال:
Sperm motility is one of the three fundamental tenets of semen analysis providing diagnostic and prognostic information for both natural and assisted reproduction technology (ART) conception. The landmark papers of John MacLeod and Ruth Gold demonstrated clear differences between subfertile and fertile men in sperm motility (MacLeod and Gold, 1951) which have been confirmed by a plethora of sub...
CatSper family proteins are putative ion channels expressed exclusively in membranes of the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function. CatSper1 is not needed for other developmental landmarks, including regional distributions of CaV1.2, CaV2.2, and...
The last few years have seen an explosion in the number of voltage-dependent ion channel sequences detected in sperm and testes. The complex structural paradigm of these channels is now known to include a pore-forming alpha1 subunit(s) whose electrophysiological properties are modulated by an intracellular beta subunit, a disulfide-linked complex of a membrane-spanning delta subunit with an ext...
T he spermatozoon is a marvelous machine designed by nature for the single task of finding an oocyte, delivering its genetic payload, and initiating the formation of a new embryo. Like many of the most specialized and sophisticated mechanical creations of humans, the sperm is fitted with unique components and stripped of unneeded hardware, including most of its biosynthetic equipment. As a cons...
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