A hypothetical evolutionary pathway from a ribozyme to a catalytic RNA-protein complex (RNP) is proposed and examined. In this hypothesis for an early phase of molecular evolution, one RNA-RNA interaction in the starting ribozyme is replaced with an RNA-protein interaction via two intermediary stages. At each stage, the original RNA-RNA interaction and a newly introduced RNA-protein interaction...

A Multi-objective optimization procedure has been developed to determine some kinetic parameters of free radical polymerization of vinyl acetate based on genetic algorithm. For this purpose, mathematical modeling of free radical polymerization of vinyl acetate is carried out first and then selected kinetic parameters are optimized by minimizing objective functions defined from comparing exp...

the effect of physiological concentrations of caffeine (purified from persian tea) on adenosine deaminase (ada) activity at physiological and pathological concentrations of adenosine (as substrate) in 50 mm tris-hcl buffer (ph 7.3) at 37°c was investigated, using uv-vis spectroscopy. ada exhibited a bi-phasic activity behavior and both phases showed positive cooperativities indicating adenosine...

Kinetic modeling of NH3 Selective Catalytic Reduction (NH3-SCR) NOx in Cu-chabazite washcoated monolithic reactors has recently become an important task for design, control and calibration heavy-duty engine aftertreatment systems. Development detailed accurate kinetic models rely on the correct simulation NO2 storage at different conditions. Here, schemes adsorption desorption were developed co...