•m6A is an endogenous adenosine A3 receptor ligand with higher potency than •Extracellular m6A mainly stems from ribosomal RNA and mRNA •Cytotoxic stimulation induces release via lysosome-mediated catabolism facilitates allergy inflammation About 150 post-transcriptional modifications have been identified in all kingdoms of life. During catabolism, most modified nucleosides are resistant to deg...