Case Description- A seven-year-old male donkey was admitted with a history of left scrotal swelling with ulcerating wound since 2 years.Clinical Findings- The left scrotum was painful. There was ulcerating and hypergranulating wound discharging bloody discharge. The wall of the scrotum was found thick and infiltratedwith soft slimy non capsulated and lobulated fibrous tissue masses. The left te...

Self-castration and penile amputation are rare life-threatening types of genital self-mutilation. The microsurgical technique replantation is the gold standard; however, there conflicting reports successful macrosurgical replantations. Being rare, this condition may even be mistaken as criminal mutilation. surgical management evolves over a few case series; therefore, it prudent to publish such...

UNLABELLED PURPOSES AND APPROACH: Acute castration and/or tailing distress in lambs has been examined extensively during the last decade. At least 59 different approaches to assessing and alleviating this distress have been reported so that the literature is quite complex. The purpose of this paper is to provide an overview of the literature on castration and/or tailing distress, where the dist...

Male rat copulatory ability decreases dramatically following castration. This may be due in part to the impairment of medial preoptic area (MPOA) dopamine (DA) release. Previous studies showed that extracellular DA levels in the MPOA of castrates were lower than in intact males, both during basal conditions and in the presence of a receptive female. However, tissue levels of DA in the MPOA were...

Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease. We hypothesized that ongoing steroidogenesis within prostate tumors and the maintenance of intratumoral androgens may contribute to castration-resistant growth. Usin...

This study addresses, in an animal tumor model, the clinical problem of "escape from castration inhibition." Somatuline (BIM-23014C), an octapeptide analogue of somatostatin with enhanced potency and longer duration of biological activity was administered as a therapeutic agent, over a period of 90 and 197 days, to male Copenhagen rats bearing syngeneic Dunning R-3327-H prostate tumors. Androge...

INTRODUCTION Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarring. We hypothesized that this renal phenotype might be modulated by androgens. Thus the aim of our study was to elucidate the impact of gonadectomy in ET-1 transgenic mice on k...

Reduced testosterone as a result of catabolic illness or aging is associated with loss of muscle and increased adiposity. We hypothesized that these changes in body composition occur because of altered rates of protein synthesis under basal and nutrient-stimulated conditions that are tissue specific. The present study investigated such mechanisms in castrated male rats (75% reduction in testost...

a 6-year-old male crossbred dog was referred to the veterinary medical teaching hospital of islamic azad university of karaj with the history of abdominal distention, rectal tenesmus and stranguria. abdominal radiographs and ultrasonography indicated large distended urinary bladder and prostatic enlargement. ecg showed temporary episodes of atrial standstill. the only abnormalities detected by ...

Identification of defined cell populations with stem/progenitor properties is key for understanding prostate development and tumorigenesis. Here we show that the polycomb repressor protein Bmi1 marks a population of castration-resistant luminal epithelial cells enriched in the mouse proximal prostate. We employ lineage tracing to show that these castration-resistant Bmi1-expressing cells (or CA...