When undergraduate biology students learn to explain biological mechanisms, they face many challenges and may overestimate their understanding of living systems. Previously, we developed the MACH model of four components used by expert biologists to explain mechanisms: Methods, Analogies, Context, and How. This study explores the implementation of the model in an undergraduate biology classroom...

MOTIVATION One of the major bottlenecks with ab initio protein folding is an effective conformation sampling algorithm that can generate native-like conformations quickly. The popular fragment assembly method generates conformations by restricting the local conformations of a protein to short structural fragments in the PDB. This method may limit conformations to a subspace to which the native ...

Oral tongue squamous cell carcinomas (OTSCC) are a homogeneous group of tumors characterized by aggressive behavior, early spread to lymph nodes and a higher rate of regional failure. Additionally, the incidence of OTSCC among younger population (<50yrs) is on the rise; many of whom lack the typical associated risk factors of alcohol and/or tobacco exposure. We present data on single nucleotide...

The estimation of prediction quality is important because without quality measures, it is difficult to determine the usefulness of a prediction. Currently, methods for ligand binding site residue predictions are assessed in the function prediction category of the biennial Critical Assessment of Techniques for Protein Structure Prediction (CASP) experiment, utilizing the Matthews Correlation Coe...

High expression of the anti-apoptotic TNFAIP8 is associated with poor survival patients diffuse large B-cell lymphoma (DLBCL), and one functions to inhibit pro-apoptosis Caspase-8. We aimed analyze immunohistochemical Caspase-8 (active subunit p18; CASP8) in a series 97 cases DLBCL from Tokai University Hospital, correlate other pathway-related markers, including cleaved Caspase-3, PARP, BCL2, ...

We modify the recent analytic formula given by Allen and Casper [1] for the rate at which piecewise linear cosmic string loops lose energy to gravitational radiation to yield the analogous analytic formula for the rate at which loops radiate momentum. The resulting formula (which is exact when the effects of gravitational back-reaction are neglected) is a sum of O(N4) polynomial and log terms w...