WATANABE, H., HIWATASHI, N. and GOTO, Y. Biopsy under Direct Vision for the Diagnosis of Crohn's Disease. Tohoku J. exp. Med., 1979, 129 (1), 1-8-In order to clarify the role of biopsy in distinguishing Crohn's disease from intestinal tuberculosis before surgery, the histologic findings of the biopsy specimens from 8 cases of Crohn's disease were investigated in comparison with those from 19 ca...

Tuberculous pleural effusion (TBPE) is treatable and curable, and hence it is important to establish the diagnosis and initiate treatment early. However, its diagnosis is not straightforward and depends on the demonstration of Mycobacterium tuberculosis in the pleural fluid or pleural biopsy specimen, or demonstration of caseating granulomas in the pleura. Due to the paucibacillary nature of th...

Sarcoidosis is an idiopathic inflammatory disorder characterized by the presence of non-caseating tissue granulomas most commonly affecting lungs, lymph nodes and skin. Sarcoid skeletal involvement is relatively uncommon and in particular tenosynovitis. We describe an unusual case of sarcoidosis presenting with granulomatous tenosynovitis as the only manifestation of the disease, illustrating t...

Gallbladder tuberculosis (GT) is an extremely rare condition. This is thought to be due to the protective property of bile against the infection. Clinical and radiological diagnosis of GT is difficult. We describe a case of GT who initially presented to us with jaundice, a right hypochondrial mass and computed tomographic findings suggestive of gallbladder empyema. Diagnosis was made from histo...

49 year old female, a known case of thalassemia minor with hypothyroidism on treatment, presented with left sided massive pleural effusion. Pleural tapping revealed exudative effusion and she was started on four drug AKT. She had recurrent pleural effusions and required repeated aspirations. Thoracoscopic pleural biopsy revealed non caseating granulomas. She continued to deteriorate after 8 mon...

Introduction Axial spondyloarthritis (SpA) is an inflammatory disease that predominantly affects vertebral and sacroiliac joint. Sarcoidosis is an inflammatory multi-system disease associated with the formation of non-caseating granulomas within involved systems (1). Both diseases can involve ocular manifestations of which anterior uveitis are common feature. Articular involvement has been repo...

A 64-year-old woman with ovarian carcinoma that had been treated with high-dose chemotherapy and autologous bone marrow transplantation presented with a maculopapular rash on the extremities and miliary infiltrates evident on chest roentgenogram. Transbronchial biopsy specimens revealed caseating granulomas, and cultures grew Mycobacterium terrae. Six weeks after therapy with isoniazid, rifampi...

Sir: Granulomas both of the foreign body and delayed hypersensitivity (immune) type are usually part of tissue-based inflammatory processes. In some diseases such as sarcoidosis, which are characterized by granuloma formation, an association with lymphatic vessels does not appear to be a feature. In Crohn’s disease, it is a frequent occurrence. In addition, granulomatous lymphangitis of the scr...

Primary pancreatic tuberculosis is an extremely rare entity, even in tuberculosis endemic areas. A 22-year-old male presented with features of obstructive jaundice. Ultrasonography and computed tomography scan showed mass in the pancreatic head for which he underwent a pancreatoduodenectomy. Histological examination of the specimen showed caseating granulomas. Antituberculous medicines were sta...