Firstly,we are study to formulate and test a topical gel containing of Itraconazole micro- emulsion (ITZ). The Formulation micro researchis necessary before its thepreformulation Itraconazole. To estimatethe maximal solubility ITZ in oils, surfactants co- were investigated estimatefilling material potential. In reference the region, with Karanj oil as phase, use surfactant Tween-80 aDiamethyl C...

The use of conventional drugs for the treatment pain and inflammation has largely resulted in various side effects. These challenges have triggered search alternative therapy such as herbal medication that may serve a safe, effective, alternate approach to managing inflammation. Vitex negundo, potential lipophilic molecule, possesses limited solubility permeability. Emulgels are either water-in...

Objective: To assess the association among serum insulinlike growth factor I (IGF-I) concentrations, bone mineral density (BMD), and biochemical markers of bone turnover in a large group of postmenopausal women from the general population. Design: As an extension of a larger epidemiological study, the Iranian Multicentral Osteoporosis Study, a total of 406 healthy postmenopausal women (age, 59....

OBJECTIVE Periodontitis is one of the most important chronic inflammatory dental diseases arising from the destructive actions caused by a variety of pathogenic organisms presented in the oral cavity. The aim of this study is the preparation and in vitro evaluation of films for the local treatment of periodontal pockets. METHODS The prepared films contained either metronidazole (Mtr), for its...

Hypertension crisis is one of the main health problems and its effective treatment is of high importance. For this purpose, fast-disintegrating and sustained release formulations of captopril, as a drug of choice, were prepared using conventional mucoadhesive polymers hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (Na-CMC), hydroxypropyl cellulose (HPC), Carbopol 934 (CP93...

Mucoadhesive nanosuspension of ciprofloxacin was designed in order to improve the solubility, bioavailability and efficacy for the treatment of typhoid fever. The identity and purity of drug was established. The compatibility of drug with various excipients was ascertained by FTIR techniques, which indicated no interaction between the drug and excipients. Four different formulations were prepar...

Abstract: Aim/Background: This research work intended to make use of prospective advantages niosomes for the improvement in topical delivery poorly soluble luliconazole. Materials and Methods: Luliconazole, an anti-fungal agent used treatment fungal infection, was successfully formulated as niosomal gel by using a polymer carbopol 934. The 32 full factorial statistical design employed means opt...

In this study, a bioadhesive dosage form of clotrimazole was designed using a combination of bioadhesive polymers Carbopol 934P, sodium carboxymethyl cellulose and sodium alginate in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablets from porcine vaginal mucosal membrane. The strong interaction between polymer and mucus lining of the t...

The purpose of this study was preparation and evaluation of sustained release matrix type ocular mini-tablets of timolol maleate, as a potential formulation for the treatment of glaucoma. Following the initial studies on timolol maleate powder, it was formulated into ocular mini-tablets. The polymers investigated in this study included cellulose derivatives (HEC, CMC, EC) and Carbopol 971P. Man...