The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and d...

A new oral drug delivery system was developed utilizing both the concepts of controlled release and mucoadhesiveness, in order to obtain a unique drug delivery system which could remain in stomach and control the drug release for longer period of time. Captopril microcapsules were prepared with a coat consisting of alginate and a mucoadhesive polymer such as hydroxy propyl methyl cellulose, car...

In present study, mucoadhesive vaginal tablet of sertaconazole was designed using a combination of mucoadhesive polymers like Carbopol 934P, chitosan, carboxymethylcellulose sodium, sodium alginate, methyl cellulose, hydroxypropyl methylcellulose and hydroxypropyl cellulose. Effervescent was incorporated into formulations to enhance swellabilty of mucoadhesive tablet. For various drug-free form...

Sustained release drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased...

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing domperidone as a model drug. Box-Behnken design was employed in formulating the GFDDS with three polymers: hydroxypropyl methylcellulose K4M (HPMC K4M) (X1), Carbopol 934P (X2) and sodium alginate (X3), as independent variables. Floating lag time (FLT), total floating time (TFT)...

The suitability of different gelling agents as MRI phantoms was evaluated in terms of homogeneity, gel stability and reproducibility. Time and effort for preparation were also taken into account. The relaxation times of various gel compositions were estimated. Carbomer-980 and Carbopol-974P were determined to be promising novel phantom materials. These gelling agents are readily available, inex...

Throughout the years, the main focus of the research activity was the applicability of different types of carboxyvinyl polymer, commercially available as Carbopols. Given the fact that the PhD thesis focused mostly on development of cutanous gel formulations, based on two traditional (Carbopol 940 and Carbopol 980) and one newly developed carboxyvinyl-type polymer (Ultrez 10), further research ...

The aim of this study was to assess the influence of qualitative and quantitative base composition on pharmaceutical availability of metronidazole. Hydrogels contain water dispersion of 2% Carbopol 971P and various concentration of glycerol, polyethylene glycol and propylene glycol were preparated. Produced formulations were neutralized to the pH 6.0-6.5 with triethanolamine, and metronidazole ...

PURPOSE β-Limit dextrin has been studied for many years as a means to investigate the internal structures of amylose and amylopectin. However its role as an excipient in the pharmaceutical industry has never been reported. This paper is the first one in a series to explore its potential use as an excipient to aid drug delivery. METHODS The bioadhesive properties of β-limit dextrin were studie...

The main aim of the present research was to encapsulate mefenamic acid in niosomes andincorporate the prepared niosomes in the carbopol gel base for sustained therapeutic action. Mefenamic acid loaded niosomes were prepared by thin film hydration technique and evaluated for entrapment efficiency, vesicular size and zeta potential. The entrapment efficiency of the prepared niosomes was found to ...