نتایج جستجو برای: carbapenems
تعداد نتایج: 3646 فیلتر نتایج به سال:
One of the urgent problems modern health care is growing resistance microorganisms to antibiotics, including carbapenems, which until recently were considered as drugs choice in treatment life-threatening infections. Enzymatic inactivation through production carbapenemase, main mechanism Gram-negative bacteria. The these infections presents significant difficulties due extremely limited arsenal...
Abstract Background To investigate the trends and correlation between antibacterial consumption carbapenem resistance in Gram-negative bacteria from 2012 to 2019 a tertiary-care teaching hospital southern China. Methods This retrospective study included data hospital-wide inpatients collected January December 2019. Data on were expressed as defined daily doses (DDDs)/1000 patient-days. Antibact...
Ertapenem is active against extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae organisms but inactive against Pseudomonas aeruginosa and Acinetobacter baumannii. Due to a lack of therapeutic data for ertapenem in the treatment of ESBL bloodstream infections (BSIs), group 2 carbapenems (e.g., imipenem or meropenem) are often preferred for treatment of ESBL-producing Enterobacteria...
activity and a wide spectrum against both Gram-positive and Gram-negative bacteria1~4). This high activity is due to good diffusion through the outer membranein Gram-negative organisms5), high affinities for penicillinbinding proteins (PBPs)6'7) and high stability and inhibitory activity against /Mactamases8). However, carbapenems were hydrolyzed by dehydropeptidase-I (DHP-I) from several anima...
background and objectives: the oprd mutation and ampc overproduction are the main mechanisms of intrinsic resistance to carbapenems such as imipenem and meropenem in pseudomonas aeruginosa . materials and methods: in this study, we investigated intrinsic resistance to carbapenems including mutation of oprd and ampc overproduction in a carbapenem-resistant p. aeruginosa isolated from a burn pati...
The synthesis and antibacterial activity of the title compounds having an isoxazolidine ring at the C-2 position are described. These derivatives were synthesized by the 1,3-dipolar cycloaddition reaction of nitrone with 2-vinyl carbapenems. This 1,3-dipolar cycloaddition reaction proceeded regioselectively to give diastereomeric isomers of 2(-isoxazolidin-5-yl)carbapenems. It was ascertained t...
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