During peritoneal dialysis solutes and water are transported across the peritoneum, a thin “membrane” lining the abdominal and pelvic cavities. Dialysis fluid containing an “osmotic agent”, usually glucose, is infused into the peritoneal space, and solutes and water pass from the blood into the dialysate (and vice versa). The complex physiological mechanisms of fluid and solute transport betwee...

Droplets spontaneously move when they are placed at the tip of a cone surface. Using three-dimensionally-printed structures, an experimental exploration large panel configurations regarding aperture angle finds evidence for change droplet geometry while moving along conical fiber---from barrel to clamshell shape. The position this geometrical transition is estimated and two models proposed desc...

The transport of opioid analgesics across the blood-brain barrier (BBB) is an important determinant of their therapeutic effects. The human brain is protected by the BBB, which consists of brain capillary endothelial cells linked with tight junctions. It is well established that the polarized expression of numerous transporters and receptors at the brain capillary endothelial cells controls the...

Alignment of microchips with receptors is an important process step in the construction of integrated micro- and nanosystems for emerging technologies, and facilitating alignment by spontaneous self-assembly processes is highly desired. Previously, capillary self-alignment of microchips driven by surface tension effects on patterned surfaces has been reported, where it was essential for microch...

Blood-tissue transport of 42 K, 8a Rb, and 22 Na was studied in perfused gracilis muscles of dogs to ascertain the influence of capillary wall, interstitial space, and muscle cell membranes on overall transport kinetics. Single-injection and continuous-infusion techniques were used, with T-1824 or 51 Cr-hemoglobin as nondiffusible references. Results were as follows: (1) Extraction (E) of the d...

The escape of solutes from the blood during passage along capillaries in heart and skeletal muscle occurs via diffusion through clefts between endothelial cells and, for some solutes, via adsorption to or transport across the luminal plasmalemma of the endothelial cell. To quantitate the rates of permeation via these two routes of transport across capillary wall, we have developed a linear mode...

The present work numerically simulates the flow of a single isolated liquid plug (of glycerine and water, respectively) flowing in a round capillary tube (ID = 2.0 mm), to understand its local thermal transport behavior. When an isolated liquid plug moves in a capillary tube there is a difference in the advancing and receding dynamic contact angles of the two menisci, respectively. This has bee...

In tissue with a distinct orientation of the oxygen supplying structures, the capillaries, a mathematical description of oxygen transport is feasible in terms of two-dimensional diffusion in a plane perpendicular to the capillaries. Muscle tissue is an example of a highly anisotropic tissue. With some additional simplifying assumptions, a solution can be constructed in terms of capillary source...

We present a dynamic network model for modeling two-phase flow. We account for wetting layer flow, meniscus oscillation, and the dynamics of snapoff. Interfaces are tracked through pore elements using a modified Poiseuille equation for the equivalent hydraulic resistance of the fluids between the pore element centers. The model is used to investigate the effects of capillary number and viscosit...