Background and Objectives Colonization of Candida species is common in pediatric patients admitted to hematology-oncology wards. The aim of this study was to identify colonized Candida species and their susceptibility patterns in hematologic pediatric patients. Materials and Methods Samples were collected from mouth, nose, urine and stool of the patients admitted to five university hospitals ...

An oligonucleotide microarray based on the arrayed-primer extension (APEX) technique has been developed to simultaneously identify pathogenic fungi frequently isolated from invasive and superficial infections. Species-specific oligonucleotide probes complementary to the internal transcribed spacer 1 and 2 (ITS1 and ITS2) region were designed for 24 species belonging to 10 genera, including Cand...

A clinical survey was carried out in seven cities in the southern part of Nigeria to determine the relative distribution of genitourinary Candida species in symptomatic patients reporting for diagnosis and treatment. Seven Candida species were identified using the CHROMagar Candida method and the API 20C System. Candida species were represented by Candida glabrata (33.7%), Candida albicans (20....

Background and Purpose: The incidence of invasive fungal infections has been increased in recent years. The growing use of azole drugs for prophylactic and therapeutic purposes has resulted in the gradual emergence of azole-resistant species. Accordingly, the introduction of a new strategy to improve the management of Candida infections is an urgent need. Regarding this, the present study was p...

BACKGROUND Fluorescent dye Rhodamine 6G (R6G) is a substrate of multidrug resistance pumps and its accumulation is reduced in some azole-resistant Candida isolates with the upregulation of multidrug efflux transporter genes. Despite reports on species-specific differences in azole susceptibility in various Candida species, only a few studies have been reported on the R6G accumulation among clin...

Background: Pediatric patients on chemotherapy are vulnerable to invasive fungal infection especially Candida spices. Resistance to antifungal agents has increased in Candida spp., especially in non-albicans species. This study aims to assess the susceptibility of Candida spp. strains isolated from children with acute leukemia less than 18 years. Materials and Methods: This prospective cross-s...

conclusions knowledge about the susceptibility patterns of colonized candida spp. can be helpful for clinicians to manage pediatric patients with neutropenia. in this study, caspofungin was the most effective antifungal agent against the colonized candida spp. followed by conventional amphotericin b. patients and methods in this study 188 children with neutropenia were recruited, fungal surveil...

background: pediatric patients on chemotherapy are vulnerable to invasive fungal infection especially candida spices. resistance to antifungal agents has increased in candida spp., especially in non-albicans species. this study aims to assess the susceptibility of candida spp. strains isolated from children with acute leukemia less than 18 years. materials and methods: this prospective cross-se...