Pulpal response of four calcium hydroxide liners, MPC 10, MPC 12, Dycal and Pulpdent were tested on primary and permanent teeth with zinc oxide and eugenol (ZOE) and silicate as controls. Responses of the pulps were evaluatedi in Rhesus monkeys, utilizing Class V cavity preparations at 3 days, 5 and 8 weeks. An equivalent number of anterior and posterior teeth were studied for all compounds. Th...

Freshly isolated hepatocytes from phenobarbital-treated rats were incubated in the presence or absence of extracellular calcium with three differently acting liver cell toxins, namely carbon tetrachloride, bromobenzene, and ethylmethanesulfonate. In the absence of extracellular calcium these three compounds were far more toxic to the cells than in its presence. This result is inconsistent with ...

Hundreds of thousands of patients around the world have been treated with drugs that antagonize the function of calcium channels. The development of these drugs was based on the remarkable scientific discovery of calcium channels, the identification of methods to antagonize their effects, and the development of compounds to block them.' As concepts of the pathophysiology and treatment of hypert...

The divalent cation, calcium, serves as a mediator for a large number of intracellular biological responses. The advent of specific fluorogenic compounds that specifically bind to calcium has allowed investigators to study changes in Ca2+ under a variety of conditions. The purpose of this application note is to demonstrate the utility of the FLx800 fluorescence microplate reader to detect rapid...

Hundreds of thousands of patients around the world have been treated with drugs that antagonize the function of calcium channels. The development of these drugs was based on the remarkable scientific discovery of calcium channels, the identification of methods to antagonize their effects, and the development of compounds to block them.' As concepts of the pathophysiology and treatment of hypert...

PC12 cells, a clonal rat pheochromocytoma cell line, possess voltage-dependent calcium channels that bind the high affinity dihydropyridine calcium antagonist [3H]nitrendipine and other calcium channel blockers. The binding is temperature-dependent and saturable, and shows no cooperativity. The calcium antagonists inhibit potassium-induced 45Ca uptake into the cells with approximately the same ...

1. The effects of two diphosphonates, disodium ethane-I-hydroxy-l,1-diphosphonate (EHDP) and disodium dichloromethylene diphosphonate (C1,MDP) on several variables of calcium metabolism have been measured in the intact rat using the model of Aubert & Milhaud (1960). 2. The animals were bred from weaning on a diet containing 1 -3% calcium. At the age of 54 days they were switched to a diet with ...

Voltage-dependent calcium channels play a critical role in many cell functions and in many cell types ranging from protozoa to vertebrates. We have shown previously that guanine nucleotides modulate the calcium action potential and the duration of backward swimming in Paramecium, both indirect measurements of calcium channel function. To determine whether guanine nucleotides to indeed alter cal...

Most of the shell material in snails is composed of calcium carbonate but the organic shell matrix determines the properties of calcium carbonate crystals. It has been shown that the deposition of calcium carbonate is affected by the ingestion of organic compounds. We hypothesize that organic compounds not synthesized by the snails are important for shell strength and must be obtained from the ...

IT has been well established that calcium can produce various alterations in cardiac rhythm such as fibrillation, arrest and/or bradycardia." Recently, Malinow presented a standardized method for producing ventricular fibrillation in the rat by calcium injection. This method was employed in the present study to evaluate a series of anti-arrhythmic compounds which were previously found effective...