Beta-blockers and the treatment of hypertension: it is time to move on tensive treatment was commenced with a beta-blocker than for those who received a renin-angiotensin system inhibitor [rela-tive risk increase (RRI) 30%, 95% CI 11–53%] or a calcium channel blocker (RRI 24%, 95% CI 11–40%). In addition, the risk of death from any cause (RRI 7%, 95% CI 0–14%) and any cardiovascular event (RRI ...

AIMS The impact on mortality outcomes of beta-blockers and calcium blockers in post-myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) reduction. A meta-regression of randomized clinical trials was carried out to assess this relationship using weighted meta-regression of logarithm of odds ratio against absolute HR reduction. METHODS AND RESULTS Twenty-five ...

Voltage-gated calcium channels are required for many key functions in the body. In this review, the different subtypes of voltage-gated calcium channels are described and their physiologic roles and pharmacology are outlined. We describe the current uses of drugs interacting with the different calcium channel subtypes and subunits, as well as specific areas in which there is strong potential fo...

OBJECTIVES Hypotension is a common complication of spinal anesthesia and is frequent in patients with hypertension. Antihypertensive agents decrease this effect by controlling blood pressure. There are conflicting reports on the continuation of antihypertensive drugs on the day of surgery in patients undergoing spinal anesthesia. Sudden hypotension could have detrimental effect on the organ sys...

Calcium channel blockers, beta adrenergic receptor blockers and Na/K ATPase inhibitors are widely used drugs, mainly for cardiovascular diseases. Their pharmacological targets are not restricted to the cardivascular tissue, nociceptive system structures also express similar targets, which strongly suggests a direct effect on pain sensation. To evaluate the pain intensity changes in outpatient g...

Calcium channel blockers (CCB) overdose can result in cardiogenic shock and that high dose insulin euglycaemic therapy (HIET) is increasingly used to treat CCB poisoning. This case illustrates the ...

To determine the specificity of the previously demonstrated competition of verapamil with radioligand binding to a-adrenergic receptors, we examined the interaction of calcium channel blockers with aiand a2-adrenergic receptors on several tissues. Verapamil competed for [H] prazosin binding to ai-adrenergic receptors and for [H]yohimbine binding to a2-adrenergic receptors in several tissues (hu...