Hyperglycemia is common during and after Coronary Artery Bypass Graft Surgery (CABGS) and has been shown to be associated with poor clinical outcomes. In this study, we hypothesized that a moderate perioperative mean blood glucose level of <150 mg/dL improves long-term survival in cardiac surgery patients. We conducted a prospective, observational cohort study in the heart center of the Univers...

BACKGROUND Treatments for coronary heart disease (CHD) have evolved rapidly over the last 15 years with considerable change in the number and effectiveness of both medical and surgical treatments. This period has seen the rapid development and uptake of statin drugs and coronary artery revascularization procedures (CARPs) that include Coronary Artery Bypass Graft procedures (CABGs) and Percutan...

____________ _ A prospective randomized trial in 80 patients having heart surgery was undertaken to test the hypothesis that steroids (ST) (methylprednisolone, 30 mg/kg) would prevent or reduce complement activation during cardiopulmonary bypass (CPB) with membrane (MEM) or bubble (BUB) oxygenators. Group I patients had MEM and ST; Group II, MEM without ST; Group III, BUB and ST; Group IV, BUB ...

Surgery for coronary artery disease is known as coronary artery bypass grafting (CABG). It was one of the landmark operations in the history of cardiac surgery that rescued millions of people afflicted by coronary artery disease. It was first performed by Kolesov,1 was popularized by Favaloro,2 and is still the leading heart operation performed today. Current reasons for performing CABG are the...

More women than men die annually from ischaemic heart disease (IHD) in the developed world. This represents a reversal of fortune from previous decades and places women firmly as the new majority now impacted. Notably, the adverse IHD gender gap is the widest in relatively young women, where myocardial infarction (MI) mortality is 2-fold higher in women under 50 years compared with age-matched ...

ACUTE KIDNEY INJURY (AKI) is the abrupt loss of kidney function leading to the retention of nitrogenous waste products and perturbations in fluid and electrolyte balance. AKI has occurred historically in up to 7% of hospitalized patients and is associated with increased mortality, longer lengths of stay in the hospital, and increased costs of care (4, 12). Due to the aging of the population in ...

Numerous studies have demonstrated the importance of altered gene expression in disease pathophysiology. Thus, modification of gene expression has emerged as an important therapeutic strategy.1 Agents that inhibit the transcription of disease-mediating genes or transactivate the expression of genes whose products disrupt pathophysiological processes are being developed. Regulation of gene expre...

Central MessageThere remains a gap between available evidence and common practice in coronary surgery. Focused training is key to creating the specialists of future advancing this discipline.PerspectiveCoronary surgery should be considered well-defined subspecialty within cardiac It an extremely impactful discipline, yet its current implementation below state-of-the-art standards. Expertise per...