Ion channels are responsible for control of cell function in excitable tissues such as heart and brain and also in organs and tissues traditionally thought to be non- excitable including liver and epithelium. In the present research, the effect of lead (Pb2+) on Ca2+ -dependent action potential and currents was studied in F77 neuronal soma membrane of Helix aspersa. For this purpose, action pot...

3 Non-linear Objective functions 4 3.1 Production problem with set-up costs . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.2 Piecewise linear cost function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.3 Piecewise linear convex cost function . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.4 Disjunctive constraints . . . . . . . . . . . . . . . . . . . . . ...

mitochondrial functions have a major impact on t-cell functionality. in this study we characterized whether mitochondrial function in the neonatal t-cells differs from that in the adult t-cells during short t-cell activation. methods: we used fow cytometry methods to test mitochondrial mass and to monitor mitochondrial ca2+ levels, mitochondrial potential and superoxide generation in parallel w...

Hydrogen sulfide (H2S) has a variety of physiological functions. H2S reportedly increases intracellular Ca2+ concentration ([Ca2+]i) in astrocytes. However, the precise mechanism and functional role this increase are not known. Here, we examined effects on [Ca2+]i astrocytes from rat spinal cord whether affects ATP-induced signaling, which is known to be involved synaptic function. Na2S (150 ?M...

conclusions: the results of the present study indicated that oral preparation of cm with an acceptable taste is feasible. background: chlorpheniramine maleate (cm) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. objectives: t...

Introduction: Since organophosphorus compounds (OP) are toxic and designed to destroy insects and pest species, there are many hazards associated with their use. Although, the main target site of these compounds is acetylcholinesterase (AChE), however it has become increasingly evident that OPs have also other direct effects on cellular processes. In the present study, the effects of low con...