The incorporation of the C14 of glutamate-2-CI4 and glutamate-5-C14 into fatty acids by epididymal fat pads and liver slices suggests the operation of the following metabolic pathway : a-ketoglutarate + isocitrate -+ cbaconitate + citrate + acetyl CoA + oxalacetate (referred to as the backward reaction of the Krebs cycle). Fatty acid-C14 recoveries from glutamate-2-C14, glutamate5-C14, and acet...

Eutectic alloys are natural in-situ composites with near-equilibrium structures, impressive strength-ductility trade-off, and perfect castability. In the current study, novel eutectic Al-Cr-Nb-Ti-Zr refractory high entropy (RHEAs) were designed using a CALPHAD (CALculation of PHAse Diagrams) approach. A starting Nb30Ti40Zr30 (at.%) alloy was based on single-phase bcc solid solution. Alloying Cr...

nine labeled either with C'4 or N'5. Considerable controversy has developed as to which one of these tracer compounds gives an accurate measurement of the “relativeturnover-rate― of the nucleic acids. In order to determine the “absolute turnover rate― of the nucleic acids, it is necessary to know the specific activity of the immediate precursor of the nucleic acids. Since even the ident...

Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strategy to fight resistant fungal isolates. Recently, amphiphilic tobramycin analogu...

Despite the importance of accurate assessment for low-density lipoprotein cholesterol (LDL-C), the Friedewald formula has primarily been used as a cost-effective method to estimate LDL-C when triglycerides are less than 400 mg/dL. In a recent study, an alternative to the formula was proposed to improve estimation of LDL-C. We evaluated the performance of the novel method versus the Friedewald f...

Amethopterin in toxic amounts, whether given in a single dose or in repeated daily doses, produced no observable inhibition of the nicotinamide-induced synthesis of diphosphopyridine nucleotide in mouse liver in vivo. Likewise, no inhibition was de tected of the incorporation of formate-C14 into the total liver acid-soluble adenine. However, administration of amethopterin sufficient to produce ...