In the search for rational targets for drug development in cancer, receptor tyrosine kinases have become a favorite. The rationale for directing efforts to developing inhibitors of these receptors is compelling. Mutated or overexpressed growth factor receptors play a pivotal role in malignant transformation and in maintaining the growth of cancers in model systems. Strategies that inactivate gr...

Staniaszek M., Szczechura W., Marczewski W. (2014): Identification of a new molecular marker C2-25 linked to the Fusarium oxysporum f.sp. radicis-lycopersici resistance Frl gene in tomato. Czech J. Genet. Plant Breed., 50: 285–287. Fusarium oxysporum Schlecht. f.sp. radicis-lycopersici Jarvis & Schoemaker (FORL) is a saprophytic fungus, responsible for the fusarium crown and root rot disease in...

Peptide growth factors regulate normal cellular proliferation and differentiation through autocrine and paracrine pathways and are involved in cancer development and progression. Among the endogenous growth factors, the epidermal growth factor (EGF)-related proteins play an important role in the pathogenesis of human cancer. In fact, overexpression of EGF-related growth factors such as transfor...

Peptide growth factors regulate normal cellular proliferation and differentiation through autocrine and paracrine pathways and are involved in cancer development and progression. Among the endogenous growth factors, the epidermal growth factor (EGF)-related proteins play an important role in the pathogenesis of human cancer. In fact, overexpression of EGF-related growth factors such as transfor...