chemokines and their receptors  play an important  role in the  late inflammatory stage of asthma. in this study, we aimed to investigate polymorphisms of mcp-1 (ccl2), ccr2 and ccr5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features. mcp-1   (a/g   -2518),  ccr2   (+/64i), ...

background: tuberculosis is a disease with high morbidity, caused mainly by mycobaterium tuberculosis (m.tb.). dna vaccines show a promising future due to their unique advantages over conventional methods. the early-secreted antigen target (esat)-6 and culture filtrate protein (cfp)-10 of m.tb. antigens have been identified as vaccine candidates against mycobacteria and used as subunit vaccines...

2-(methylamino) pyridine (hmap) reacts with meli in thf and generates the lithium salt (limap). further reaction of [cu(tmeds)2][cucl2] (tmeda=tetramethylethylenediamine) with one equivalent of this ligand in thf leads to the formation of a yellow dimeric cu(i) complex, [cu(map)]2. analytical data, molecular weight, and magnetic susceptibility measurements, confirm the formula [cu(map)]2 .

in this paper, we have studied the effect of population on iranian economic growth by using optimal growth theory. optimal growth theory is a nonlinear dynamic planning. classical approaches in mathematics are used for solving these nonlinear systems. but, in this study, we have used genetic algorithm (ga) method. as results show, it seems that population growth in previous years (1350- 1386), ...

abstract background: rhabdomyosarcoma is the most common soft tissue sarcoma among children which has two major subtypes: embryonal rhabdomyosarcoma (erms) and alveolar rhabdomyosarcoma (arms). distinction between these subtypes is mandatory to choose proper treatment and to determine prognosis. histopathologic study is the main method, but nowadays molecular studies like pcr are also used. the...

objective(s): tlr-4 activates a number of inflammatory signaling pathways. also, ampk could be involved in anti-inflammatory signaling. the aim of this study was to identify whether stimulation of ampk could inhibit lps-induced tlr-4 gene expression in mice hearts. materials and methods: heart ampk activity and/or tlr-4 expression was stimulated in different mice groups, using respectively ip i...

results at high concentrations (40 and 100 μm), apoptosis was demonstrated and it was clearly more prominent in hepatocytes exposed to celecoxib loaded liposomes. conclusions our results showed that celecoxib loaded liposomes robustly induced apoptosis, an action that can potentially make it more relevant than the usual form for chemopreventive strategies and also may raise concerns about its t...

background: variations in cytotoxic t lymphocyte antigen-4 (ctla-4) affect the expression and function of this protein. objective: we aimed to investigate the association of +49 a/g (rs231775), +1822 c/t (rs231779) and +6230 a/g (ct60, rs3087243) genetic variations, as well as the merged haplotypes in ctla-4 gene with susceptibility to, or progression of head and neck cancer. methods: eighty pa...