Asymmetric dimethylarginine (ADMA) is a competitive endogenous inhibitor of nitric oxide synthase with a key role in the pathophysiology of endothelial dysfunction, in the progression of atherosclerosis and in cardiovascular diseases. Statins, renin-angiotensin-aldosterone system inhibitors, blood glucose lowering agents, insulin sensitizers, beta-blockers, estrogen replacement therapy, antioxi...

We define a quantum–mechanical time operator that is selfadjoint and compatible with the energy operator having a spectrum bounded from below. On their common domain, the operators of time and energy satisfy the expected canonical commutation relation. Pauli’s theorem is bypassed because the correspondence between time and energy is not given by the standard Fourier transformation, but by a var...

In spite of aggressive multi-modality treatments, patients diagnosed with anaplastic astrocytoma and glioblastoma continue to display poor median survival. The success of our current conventional and targeted chemotherapies are largely hindered by systemic- and neurotoxicity, as well as poor central nervous system (CNS) penetration. Interstitial drug administration via convection-enhanced deliv...

BACKGROUND Factor (F)VIIa-based bypassing not always provides sufficient hemostasis in hemophilia. OBJECTIVES To investigate the potential of engineered activated factor V (FVa) variants as bypassing agents in hemophilia A. METHODS Activity of FVa variants was studied in vitro using prothrombinase assays with purified components and in FV- and FVIII-deficient plasma using clotting and throm...

Bypassing health facilities for childbirth can be costly both for women and health systems. There have been some reports on this from Sub-Saharan African and from Nepal but none from India. India has implemented the Janani Suraksha Yojana (JSY), a large national conditional cash transfer program which has successfully increased the number of institutional births in India. This paper aims to stu...

With increasing core-count, the cache demand of modern processors has also increased. However, due to strict area/power budgets and presence of poor data-locality workloads, blindly scaling cache capacity is both infeasible and ineffective. Cache bypassing is a promising technique to increase effective cache capacity without incurring power/area costs of a larger sized cache. However, injudicio...