نتایج جستجو برای: buthionin sulfoximine
تعداد نتایج: 1253 فیلتر نتایج به سال:
The first alpha-difluoromethyl sulfoximine compound, 2, was successfully prepared by using the copper(II)-catalyzed nitrene transfer reaction. Compound 2 was found to be a novel and efficient difluoromethylation reagent for transferring the CF(2)H group to S-, N-, and C-nucleophiles. Deuterium-labeling experiments suggest that a difluorocarbene mechanism is involved in the current difluoromethy...
The human glioma-derived cell line D-54 MG and the human medulloblastoma-derived cell line TE-671 have been shown to be sensitive in culture to the pharmacological interference with glutamine metabolism by acivicin, 6-diazo-5-oxo-L-norleucine, and methionine sulfoximine. Using as a guide the multiple contributions of glutamine to the biosynthesis of proteins, purines, and pyrimidines, we now ha...
Activated macrophages and granulocytes lyse tumor cells in the presence of phorbol myristate acetate or antitumor antibody via the secretion of reactive oxygen intermediates, such as HzOz. We compared the lysis of GSH-depleted or normal tumor cells by oxidants generated with glucose oxidase or activated macrophages and granulocytes. Two independent methods were employed to deplete cells specifi...
Glutamine synthetase (GS, EC 6.3.1.2; also known as gamma-glutamyl:ammonia ligase) catalyzes the ATP-dependent condensation of glutamate and ammonia to form glutamine. The enzyme has essential roles in different tissues and species, which have led to its consideration as a drug or an herbicide target. In this article, we describe studies aimed at the discovery of new antimicrobial agents target...
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