نتایج جستجو برای: burkitt lymphoma
تعداد نتایج: 102482 فیلتر نتایج به سال:
Burkitt-type acute lymphoblastic leukemia (B-ALL) is thought as a variant of Burkitt lymphoma/leukemia and derived from mature B-cell lymphoblast.B-ALL was developed in a 10-year-old girl. Two characteristics were apparent in this case. First, the lymphoblastic cells were positive for CD10, CD19, CD20, and CD22, but negative for terminal deoxynucleotidyl transferase and surface immunoglobulins,...
Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile. The latter is mostly driven by the MYC over-expression associated with the characteristic translocation (8;14) (q24; q32) or with variant lesions. Additional genetic events can contribute to Burkitt Lymphoma pathobiology and retain cl...
Reduced levels of the cyclin-dependent kinase inhibitor p27(Kip1) connote poor prognosis in cancer. In human Burkitt lymphoma and in precancerous B cells and lymphomas arising in Emu-Myc transgenic mice, p27(Kip1) expression is markedly reduced. We show that the transcription of the Cks1 component of the SCF(Skp2) complex that is necessary for p27(Kip1) ubiquitylation and degradation is induced...
Clinical presentation in extranodal and nodal sites of rapidly expanding masses in high-risk populations suggests Burkitt lymphoma (BL). Most patients present with advanced disease because of the rapid rate of tumor growth. BL cells have a remarkably short doubling time. Children in equatorial Africa and Papua New Guinea have endemic BL and present with facial tumors in the jaw or orbit, abdomi...
Burkitt Lymphoma (BL) is a high grade Non-Hodgkins Lymphoma (NHL) that is characterized histopathologically by a mass of diffuse small non-cleaved B cell lymphocytes [1,2]. It is a highly aggressive lymphoma that frequently presents in extranodal sites with a very high proliferation rate. It is the fastest growing tumour, characterized by explosive growth with a doubling time of 24 hours. BL is...
Background Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Accordingly, they were proposed as a new modality in the treatment of Burkitt lymphoma. However, they induce apoptosis with little if any appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can also kill protozoa (such as Trichomo...
Introduction: Primary gastric lymphoma (PGL) is a rare tumor, whose differential diagnosis may become complicated without precise immunohistochemistry (IHC) and genetic analysis. Case Presentation: A 33-year-old woman presented with gastric cancer and had undergone gastrectomy without precise IHC and staging in another center. Inappropriate IHC after surgery showed diffuse large B-cell lymphom...
RATIONALE Burkitt lymphoma (BL) is an endemic tumor in Africa but rare sporadic cases are diagnosed in Europe. PATIENT CONCERNS A 60-year-old woman was hospitalized with fulminant hematemesis and a history of recurring melena. DIAGNOSES The upper gastrointestinal endoscopy revealed a tumor of the antrum. INTERVENTIONS Emergency gastrectomy was performed. OUTCOMES Gross findings revealed...
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