Chronic bullous disease of childhood (CBDC) is an autoimmune blistering disease that is characterized by Immunoglobulin A (IgA) deposits at the basement membrane zone. IgA autoantibodies (aAbs) from the serum of patients with CBDC react with antigens of 97 kDa (LABD97) and 120 kDa (LAD-1), and both of which are fragments of the extracellular domain of bullous pemphigoid 180 (BP180, type XVII co...

Background: Bullous pemphigoid (BP) is an autoimmune cutaneous blistering disorder. The precise precipitating etiology is not clear. There has been documented Drug-induced BP in case reports. Case report: We describe a case of a 44year old female with a past medical history of Psoriasis, who developed bullous pemphigoid. She had previously been on maintenance dose of 10mg intravenous methotrexa...

Sir, The literature reports several cases of psoriasis associated with bullous diseases, the most frequent of which is bullous pemphigoid (1 – 3). By contrast, pemphigusrelated disorders are less frequently reported in association with psoriasis. We report the case of a patient with long-standing psoriasis who developed pemphigus foliaceus and discuss the possible pathogenic relationship betwee...

The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and/or oral mucosa in combination with circulating and deposited autoantibodies reactive with (hemi)desmosomes. Koch's postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch's pos...

Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination systemic and topical corticosteroids as well other immunomodulatory drugs. Dupilumab fully human monoclonal antibody acts antagonist against IL4Ra traditionally used the treatment atopic dermatitis. We present 80-year-old man moderate to severe bullous succe...

Adverse reactions of subcutaneous low molecular weight heparin or unfractionated heparin could be complications by bleeding, heparin-induced thrombocytopenia, drug-induced liver injury, osteoporosis, and cutaneous reactions. Heparin-induced skin lesions vary from allergic reactions like erythema, urticaria, eczema to intradermal microvascular thrombosis associated with heparin-induced thrombocy...

Dear Editor, Nicotinamide with tetracycline or doxycycline is used in the treatment of bullous pemphigoid. Nicotinamide is used in doses of 1500 to 2000 mg/day in divided doses in these cases. Nicotinic acid/laropiprant (Tredaptive®) is a lipid lowering agent which contains 1000 mg of nicotinic acid (niacin) and 20 mg of laropiprant which is a selective antagonist of prostaglandin D2 receptor. ...

Abstract Bullous pemphigoid and psoriasis are two well‐characterised chronic autoimmune diseases that may be triggered by drugs, infections or vaccines. The coexistence of the is a rare event but more extraordinary if incited messenger RNA (mRNA) COVID‐19 vaccination. A 62‐year‐old Filipino male experiencing flare‐up his long‐standing vulgaris presented with new onset tense blisters on legs 2 d...