background: the b-cell defect in x-linked agammaglobulinemia (xla) is caused by mutations in the gene for bruton's tyrosine kinase (btk). btk mutations result in deficient expression of btk protein in peripheral blood monocytes. methods: using the anti-btk monoclonal antibody (48-2h), a flow cytometric analysis of intra cytoplasmic btk protein expression in monocytes was performed to ident...

hydrates are crystalline compounds similar to ice, with guest molecules like methane and ethane trapped inside cavities or cages formed by the hydrogen bounded framework of water molecules. these solid compounds give rise to problems in the natural gas oil industry because they can plug pipelines and process equipments. low dosage hydrate inhibitors are a recently developed hydrate control tech...

Abstract We report our investigation of the utility peptide crosslinking cytochrome P450 enzymes from biarylitide biosynthesis to generate a range cyclic tripeptides simple synthons. The crosslinked produced by this include both tyrosine‐histidine (A− N −B) and tyrosine‐tryptophan O tripeptides, latter rare example phenolic crosslink an indole moiety. Tripeptides are easily isolated following p...

1. The solubilities and differential heats of solution of d-tyrosine, dl-tyrosine, diiodo-dl-tyrosine, dibromo-l-tyrosine (hydrated), dibromo-l-tyrosine (anhydrous), and dichloro-l-tyrosine (hydrated) have been determined. 2. Evidence has been advanced that dl-tyrosine is a compound. 3. From the solubility determinations at various acidities, the apparent acid and basic dissociation constants o...

A previous study has shown that Cetrimonium bromide a slight cytotoxicity to head and neck cancer cells due the presence of cationic quaternary amine group in this molecule affects function mitochondria.The same also found increased when combined with gamma radiation could be used treat mice vivo tumor model.In current study, an vitro photochemical reaction between chloride tyrosine was investi...

Hydrates are crystalline compounds similar to ice, with guest molecules like methane and ethane trapped inside cavities or cages formed by the hydrogen bounded framework of water molecules. These solid compounds give rise to problems in the natural gas oil industry because they can plug pipelines and process equipments. Low dosage hydrate inhibitors are a recently developed hydrate control tech...

Tyrosine kinase inhibitors (TKIs) are the mainstay of current management chronic myeloid leukemia (CML) [1]. With introduction imatinib, many CML patients in phase (CML-CP) we...

We recently isolated a novel co-activator of peroxisome proliferator-activated receptor γ, helicase with zinc finger 2 (HELZ2). HELZ2 null mice were resistant to diet-induced obesity and NAFFL/NASH, was phosphorylated at tyrosine residues. In order find factor related HELZ2, we analyzed products co-immunoprecipitated by mass spectrometry analyses. identified proline- glutamine-rich (SFPQ) as pr...

Recently, anti-cancer targeting drugs are directed against specific molecules and signaling pathways. These agents have reasonable specificity, efficacy less side effects. Tyrosine kinases, which play an essential role in growth factor regulation, significant targets this type of therapy. Synthesized numerous tyrosine-kinase inhibitors (TKIs), such as substituted indolin-2-ones, effective anti-...