The review considers the main groups of drugs used to treat bronchial asthma depending on severity disease. mechanisms action and effectiveness taking anti-asthma drugs, their combinations side effects are covered in detail. Particular attention is paid targeted therapy with biological which aimed at reducing allergic inflammatory response patients severe asthma. This approach allows change nat...

Using hippuryl-L-histidyl-L-leucine as a substrate analog, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma. There were significantly low activities of serum ACE in 115 patients with bronchial asthma irrespective of the presence or absence of acute attack. The activity of serum ACE was reduced more markedly in the chronic type of b...

Chronic airway inflammation, one of the pathophysiologic features of bronchial asthma, is suspected to be responsible for irreversible pathological changes of airways, called airway remodeling. To examine the mechanisms of airway remodeling in asthma, we investigated the expression of epidermal growth factor (EGF) and its receptor immunohistochemically in asthmatic human airways. Airway specime...

The number of senile patients with therapy resistant bronchial asthma, chronic pulmonary emphysema increases due to the habit of smoking and increased number of older people, and these inflammatory pulmonary diseases are the leading causes of death worldwide. Rhinoviruses cause the majority of common colds, and provoke exacerbations of bronchial asthma and chronic pulmonary emphysema. Here, I r...

Local Treatment of Bronchial Asthma with Hydrocorfisone Powder H. HERXHEIMER, M.D., L.R.C.P.&S.Ed. MONICA K. MCALLEN, M.D., M.R.C.P., and D. A. WILLIAMS, M.D., M.SC. F.R.C.P. Bronchial Asthma and Chronic Bronchitis Treated with Hydrocortisone Acetate Inhalations W. H. HELM, M.R.C.P., and F. HEYWORTH, M.B. ........................................................ 765 Inhalation of Hydrocortisone ...

Intermittent airflow limitation, bronchial hyperresponsiveness (BHR), airway inflammation and remodelling are key pathophysiological components of bronchial asthma [1]. BHR, an abnormal increase in airflow limitation following exposure to a stimulus, is present in almost all patients with clinically current asthma. Furthermore, patients with more severe asthma have more responsive airways than ...

Asthma is characterized by inflammation of the airways that includes eosinophils, basal membrane thickening, epithelial sloughing, vascular changes, smooth muscle hypertrophy and hyperplasia, and mucous gland hyperplasia. Recently, there have been studies on the role of hypersensitivity and inflammation in asthma, but the role of bronchial smooth muscle remains unclear. Bronchial thermoplasty i...

Asthma in children up to 5 years of age is a disease that diagnosed on the basis clinical symptoms bronchial obstruction, such as: wheezing, cough and shortness breath variable intensity duration, clinically proven reversibility obstruction improvement after chronic use inhaled glucocorticosteroids lack grounds for suspecting causes other than asthma. Treatment childhood asthma graded therapy w...