نتایج جستجو برای: breast cancer risk
تعداد نتایج: 1808040 فیلتر نتایج به سال:
Abstract Background and objectives: Breast cancer is the most prevalent one in women. Some of the common causative factors are genetic background, nutritional and environmental factors. Viruses are believed as a risk factor in this cancer, too. Recent studies reported that Human Papillomaviruses can be one of the possible risk factors of breast cancer. This study focused on investigation of the...
Background and purpose: Single-nucleotide polymorphisms (SNPs) within miRNA genes may be related with risk of cancer. A main SNP in the pre-miR-27a (rs895819) with an A to G variation was earlier identified. In this study, we aimed to explore any association between SNP rs895819 in the miR-27a gene and breast cancer susceptibility. Materials and methods: This case-control study included 120 br...
Risk of Breast cancer in women with palpable breast cysts
Background and Aim: Breast cancer is the leading cause of cancer death among women, both in Iran and worldwide. The wide variation in breast cancer incidence in different geographical areas calls for studies to clarify the role of potential risk factors. In this study we looked at some factors that could be involved in the pathogenesis of breast cancer. Material and Methods: This matched case...
Background: Breast cancer is one of the most common worldwide malignancies among women. Biological data suggest that damage induced by endogenous and exogenous factors affects the integrity of DNA and associated with susceptibility to breast cancer. Single nucleotide polymorphisms (SNPs) in DNA repair genes can associated with differences in the repair efficiency of DNA damage and may affect br...
Status of FAS and FAS Ligand Gene Polymorphisms in Patients wi th Breast Cancer in Northeastern IRAN
Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evalua...
Background: Leptin is an adipokine made by fat cells and plays a key role in proliferation, cell survival, migration and immune response. Several studies have suggested that individuals with high serum leptin concentrations would increase the risk of breast cancer. G -2548A polymorphism in the leptin gene is located in the promoter region and is associated with the change of leptin serum level....
background: dna methyltransferase-3b (dnmt3b) is an important enzyme responsible for maintaining the dna methylation pattern in eukaryotic cells. in this study we have investigated the correlation between the 46359c→t polymorphism in the dnmt3b gene and the risk of breast cancer incidence among sporadic breast cancer patients in fars province, southern iran. methods: in this case-control study,...
breast cancer is a malignant tumor and the most common cancer among american women that starts from cells of the breast. the growth of the size of data exceeds the ability of humans to analyze the data. so we need some intelligent machines that can analyze datasets intelligently for us. we propose a multi nominal logit model to evaluate correlation between risk factors of breast tumor. our mode...
Introduction: Breast cancer is the most common malignancy in women worldwide. BRCA1 is a tumor suppressor gene that is involved in DNA-damage repair. One of the significant risk factors of breast cancer is the family history. BRCA1 gene consists of 24 exons that encode a protein with 1863 amino acids. Exon 11 is the largest exons and most of the disease-linked mutations have been found in it. I...
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