BACKGROUND The aim of this dose-finding study was to evaluate the dose-response relationship of sugammadex and neostigmine to reverse a commonly observed level of incomplete recovery from rocuronium-induced neuromuscular block, that is, a train-of-four ratio (TOFR) ≥0.2. METHODS Ninety-nine anaesthetized patients received rocuronium 0.6 mg kg(-1) i.v. for tracheal intubation and, if necessary...

Abstract Poly(ADP-ribosyl)ation (PAR) is a versatile and complex posttranslational modification composed of repeating units ADP-ribose arranged into linear or branched polymers. This scaffold linked to the regulation many cellular processes including DNA damage response, alteration chromatin structure Wnt signalling. Despite decades research, principles mechanisms underlying all steps PAR remov...

The presence of residual neuromuscular block is often difficult to assess. Muscle tension or electrical activity in response to motor nerve stimulation is of limited value without control responses. Neuromuscular transmission which was suppressed by tubocurarine in the in vitro preparation could be briefly restored by application to the nerve of two or more very closely spaced stimuli; this occ...

Host-parasite checklists are essential resources in ecological parasitology, and are regularly used as sources of data in comparative studies of parasite species richness across host species, or of host specificity among parasite species. However, checklists are only useful datasets if they are relatively complete, that is, close to capturing all host-parasite associations occurring in a partic...

ABSTRACT The artificial flowering induction in mango tree is the most important crop management orchards and requires greater attention from growers. involves three steps: stoppage of plant growth, branch maturation with nitrates. first stage starts application paclobutrazol to soil. However, problems use excessive concentrations are common lead accumulation residues In addition, not allowed or...

BACKGROUND Tumour necrosis factor (TNF) inhibitors enable tight control of disease activity in patients with rheumatoid arthritis (RA). Discontinuation of TNF inhibitors after acquisition of low disease activity (LDA) is important for safety and economic reasons. OBJECTIVE To determine whether infliximab might be discontinued after achievement of LDA in patients with RA and to evaluate progre...