In comparison to other cancers, gliomas are locally invasive cancers that seldom metastasize. Glioma cells infiltrate brain parenchyma up to several centimeters from the tumor core. Therefore, their recurrence occurs at the margin of tumor resection in about 90% of patients (1). Significant effort is put into analyzing peritumoral regions to understand the mechanisms of glioma recurrence after ...

BACKGROUND The treatment paradigm from postoperative whole brain radiation therapy (WBRT) to post-operative stereotactic radiosurgery (SRS) to the tumor bed has shifted with little data to evaluate whether each treatment modality confers equivalent tumor control and survival outcomes. METHODS Patients with surgical resection of single brain metastases from January 2010 to December 2014 were t...

PURPOSE This meta-analysis examined roles of several metabolites in differentiating recurrent tumor from necrosis in patients with brain tumors using MR perfusion and spectroscopy. METHODS Medline, Cochrane, EMBASE, and Google Scholar were searched for studies using perfusion MRI and/or MR spectroscopy published up to March 4, 2015 which differentiated between recurrent tumor vs. necrosis in ...

Triple negative breast cancer (TNBC) is the most aggressive subtype of cancer, with limited treatment options and high rates recurrence metastasis due to lack specific therapeutic targets. The incidence bone metastases brain also high. They are more likely relapse have a poor long-term prognosis. tumor microenvironment (TME) consists cells, variety mesenchymal cells an extracellular matrix, whi...

The differentiation of progressive or recurrent brain tumor from radiation injury after radiotherapy is difficult using conventional MR imagings(MRI) [1]. Accurate diagnosis of tumor recurrent or radiation injury is critical to determining therapy [2]. Perfusion-sensitive contrast-enhanced MR imaging(PWI), which has made it possible to obtain measurements of vascularity within brain lesions, ma...

Background: The characteristics of glioblastoma, such as drug resistance during treatment, short patient survival, and high recurrence rates, have made patients with glioblastoma more likely to benefit from oncolytic therapy. Methods: In this study, we investigated the safety sindbis virus by injecting intravenously intracranially in mice evaluated therapeutic effect carrying different combinat...

the brain is a rare site for metastasis in most extracranial pediatric solid tumors, including wilm’s tumor. outcome for these patients are generally dismal. very few cases have been reported to have good survival even after therapy. this paper reports a case of stage iv wilm’s tumor with lung metastases in a patient who developed a solitary brain metastasis five months after completion of chem...

juvenile nasopharyngeal angiofibroma (jna) is a rare, benign and locally invasive tumor. massive bleeding because of vascularity of tumor and postoperative recurrence are potential problems of management. endonasal approach reduces the rate of postoperative recurrence, intraoperative bleeding, and complications of surgery, time of operation and duration of hospitalization. in this article, we r...