نتایج جستجو برای: brain metastases
تعداد نتایج: 520732 فیلتر نتایج به سال:
Background/Aim. About 10% of patients diagnosed with systemic cancer leads to the appearance brain metastases in central nervous system. Diseased lungs, breasts, urinary and digestive tract as well melanoma skin, are increasingly treated by neurosurgeons due their dissemination creation secondary deposits brain. Methods. The retrospective study was performed at Clinic for Neurosurgery Oncology ...
Correspondence to: Dr K N Franks, Cookridge Hospital, Leeds Teaching Hospitals NHS Trust, Hospital Lane, Leeds LS16 6QB, UK; [email protected] _________________________ T en to 50% of patients with systemic malignancy develop brain metastases during the course of their disease and metastases account for more than half of all brain tumours in adults. The major originating primary tumours are ...
Brain metastases are a relatively common consequence of Stage IV melanoma. Historically, patients with brain metastases fare poorly, with median survival of only weeks to months. Patients with multiple metastases in the brain have often been overlooked in the literature, with the focus being placed more on patients with only a small number of metastases. The authors present a case of a 42-year-...
Brain Metastases in Triple Receptor - Negative Breast Cancer : Frequency , Risk Groups and Prognosis
Objectives: The aim of this retrospective analysis is to determine the frequency, pattern, risk factors and survival of triple receptor-negative breast cancer (TNBC) focusing on brain metastases. Methods: From January 2001 to December 2007, a total of 123 patients with stage I through III TNBC were treated at the Department of Clinical Oncology, Tanta University Hospital. Patients were reviewed...
Abstract Background Brain metastases show different patterns of contrast enhancement, potentially reflecting hypoxic and necrotic tumor regions with reduced radiosensitivity. An objective evaluation these might allow a prediction response to radiotherapy. We therefore investigated the potential MRI radiomics in comparison visual assessment semantic features predict early stereotactic radiosurge...
Melanoma brain metastases are common, difficult to treat, and carry a poor prognosis. Until recently, systemic therapy was ineffective. Local therapy (including surgery, stereotactic radiotherapy, and whole brain radiotherapy) was considered the only option for a chance of disease control in the brain, and was highly dependent on the patient's performance status and age, number and size of brai...
Background Immune checkpoint inhibitors are reported to be effective in patients with brain metastases. However, detailed characteristics of the brain metastasis immune microenvironment remain unexplored. Results The median tumor-infiltrating lymphocyte (TIL) category in brain metastases was 5% (1-70%). In 46 pair-matched samples, the percentages of TILs were significantly higher in primary b...
Disseminated metastatic disease, including brain metastases, is commonly encountered in malignant melanoma. The classical treatment approach for melanoma brain metastases has been neurosurgical resection followed by whole brain radiotherapy. Traditionally, if lesions were either too numerous or surgical intervention would cause substantial neurologic deficits, patients were either treated with ...
PURPOSE The increasing prevalence of distant metastases from non-small cell lung cancer (NSCLC) indicates an urgent need for novel therapeutic modalities. Brain metastasis is particularly common in NSCLC, with severe adverse effects on clinical prognosis. Although the molecular heterogeneity of NSCLC and availability of various targeted agents suggest personalized therapeutic approaches for suc...
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