Stroke is one of the leading causes of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. The "cerebral" ischemic preconditioning mechanism is characterized by a brief episode of ischemia that renders the brain more resistant against su...

We have previously shown that the cell death promoting protein Bcl-2 interacting mediator of cell death (Bim) is ubiquitinated and degraded following a neuroprotection-conferring episode of brief ischemia (preconditioning). Here, we identify the E3ligase that ubiquitinates Bim in this model, using a proteomics approach. Using phosphorylated GSTBim as bait, we precipitated and identified by mass...

Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...

Ischemic/reperfusion brain injury (IRI) is a very severe event with the multiple etiopathogenesis. Ischemic preconditioning (IPC) is an important phenomenon of adaptation of CNS to subsequent ischemia. An altered cross-talk between intracellular calcium stores is presumed in the mechanisms of ischemic damage/protection. We show here that IRI leads to the inhibition of mitochondrial respiratory ...

objective: recent studies suggest that intermittent and prolonged normobaric hyperoxia (ho) results in ischemic tolerance to preventing ischemia brain injury. in this research attempts were made to see the changes in excitatory amio-acid transporter 3 (eaat3), tnf-α levels, and nf-κb activity following prolonged and intermittent nbho preconditioning. materials and methods: rats were divided i...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...