Background: Traumatic brain injury is believed to be a public health disorder with some complications. Post Traumatic Neurocognitive Disorders (PTND) received much attention among these complications because of the high prevalence of mild traumatic brain injuries. On the other hand, advanced neuroimaging is increasingly becoming an exciting modality in the field of traumatic brain injury. Magne...

Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...

main goal in the management of patients with severe traumatic brain injury (tbi) is control of intracranial pressure (icp). decompressive craniectomy is an accepted technique for control of refractory intracranial hypertension in patients with severe tbi. because of high complication rate after decompressive craniectomy, new techniques such as basal cisternostomy have developed. we herein repor...

Abstract Date Presented 04/20/2023 This study explored drug and alcohol use among people with traumatic brain injury (TBI) in both rural urban areas. Study findings suggest that TBI from families reporting unmet needs engaged more frequent substance use. Primary Author Speaker: Steven Wheeler Additional Authors Speakers: Amanda Acord-Vira

objective(s) cytokines such as il-1β are involved in inflammatory responses. this study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain il-10 and il-1β after traumatic brain injury (tbi) in male rats. materials and methods rats were assigned into 6 groups: intact, sham, tbi, and treated rats with vehicle, celecoxib or iboprophen. cytokine concentrations wer...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases central nervous system. We hypothesize that microglia may a beneficial or detrimental TBI depending on their state activation duration. In this study, we evaluated whether results spatiotemporal change phenotype it affects sensory-motor learning memory functions ...

objective(s): neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (tbi). two of these peptides are including the regulatory peptides neuromedin u (nmu) and neuromedin s (nms), and their common receptor neuromedin u2 receptor (nmur2). this study investigates the effects of physiological do...