Abstract Early-life stress is a risk factor for the development of behavioral and cognitive disorders in humans animals. Such stressful situations include social isolation early postnatal ontogenesis. Behavioral impairments associated with neuroplastic changes brain structures. We have found that after ten weeks isolation, male Wistar rats show abnormalities deficit, accompanied by an increase ...

lead is a common toxic agent which impairs various organs functions of the body. the basis of this toxicity is believed to be the negative influence on enzymatic system of cells. in the past few years, increasing consideration has been given to interactions occurring between lead and some essential metals including se and zn. based on the finding that some trace elements could reverse the toxic...

Somatotopic distribution of motor cortex and sensory fibers is theoretically fully understood. We present a case of stroke, mimicking peripheral palsy, with finger paralysis attributed to cortical lesion. The patient’s brain MRI may be useful to further understand the somatotopic representation of fingers in precentral and postcentral gyrus.

introduction: considering the anticonvulsant effects of a1 adenosine receptors and the anatomical connections between pjriform cortex and amygdala, in this study, the role of a1 adenosine receptors activity of piriform cortex neurons on amygdala kindled seizures was investigated in rats. material and methods: the rats were fully kindled by daily electrical stimulation of amygdala. n6-cyclohexyl...

Fractal dimensionality (FD) measures the complexity within folds and ridges of cortical subcortical structures. We tested degree that FD might provide a new perspective on atrophy-compensation hypothesis: age or disease-related atrophy causes compensatory neural response in form increased brain activity prefrontal cortex to maintain cognition. Brain structural functional data were collected fro...

Introduction: Various treatment methods for drug abusers will result in different success rates. This is partly due to different neural assumptions and partly due to various rate of relapse in abusers because of different circumstances. Investigating the brain activation networks of treated subjects can reveal the hidden mechanisms of the therapeutic methods. Methods: We studied three groups o...

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...

in this paper it has been shown that deterioration of the brain cortex capillary system and negative dynamics of cerebral tissue morphology occur under conditions of hypo kinesia. simultaneously, gamma-aminobutyric acid (gaba) and piracetam have been shown to favor the development of vasodilation and prevent further worsening of the cerebral blood supply. during the experiment, it was also esta...

Background: Hepatic encephalopathy is defined as a neuropsychiatric brain dysfunction in acute or chronic liver failure. Infection and inflammation have crucial role in its pathophysiology. The purpose of our study was to demonstrate the relationship between toll-like receptor 4 (TLR4) expression and the encephalopathy induced with endotoxin in biliary cirrhotic rats. Methods: The present stud...