drug design is generally achieved through trial and error methods, which is a time and resource consuming process and novel methods are needed to improve it. mathematical modelling is one of the possible solutions to speed up this process. in this study, we have presented box-jenkins model, to predict the vasorelaxant activity (pec50) of a set of benzopyrane compounds. we used the hyperchem sof...

User interfaces that adapt their characteristics to those of the user are referred to as adaptive interfaces. We propose Adaptive Agent Oriented Software Architecture (AAOSA) as a new way of designing adaptive interfaces. AAOSA is a new approach to software design based on an agent-oriented architecture. In this approach agents are considered adaptively communicating concurrent modules which ar...

A new approach to software design based on an agent-oriented architecture is presented. Unlike current research, we consider software to be designed and implemented with this methodology in mind. In this approach agents are considered adaptively communicating concurrent modules which are divided into a white box module responsible for the communications and learning, and a black box which is th...

Stochastic Local Search (SLS) is a simple and effective paradigm for attacking a variety of Combinatorial (Optimization) Problems (COP). However, it is often non-trivial to get good results from an SLS; the designer of an SLS needs to undertake a laborious and ad-hoc algorithm tuning and re-design process for a particular COP. There are two general approaches. Black-box approach treats the SLS ...

A parametric formulation for preliminary design of tubed-system tall buildings is presented in which some optimality criteria and practical constraints are considered. Here, a minimum compliance optimization formulation, developed by other researchers, is applied to a framed-tube structure. The tube behavior is modeled as a cantilevered box beam. Independent variable in this problem is thicknes...

background nowadays, adsorption techniques are widely used to remove certain classes of pollutants from water. objectives the aim of this study was to remove ametryn from water solutions by natural zeolite nanoparticles from the semnan region of iran. materials and methods for this purpose zeolite nanoparticles were synthesized from natural zeolite using planetary ball-mill. the zeolite nanopar...

n-methylol dimethyl phosphonopropionamide (mdpa) is one of the most utilized fire resistant (fr) finishes for cotton fabrics, utilized as part of a formulation with trimethylol melamine (tmm) to acquire better crosslinking and enhanced fr properties. the system parameters of the finishing treatment were upgraded for better fr properties and low mechanical loss to the fabric by the response surf...

In engineering design problems, we want to make sure that a certain quantity c of the designed system lies within given bounds – or at least that the probability of this quantity to be outside these bounds does not exceed a given threshold. We may have several such requirements – thus the requirement can be formulated as bounds [F c(x), F c(x)] on the cumulative distribution function Fc(x) of t...

Background & Aims: High concentrations of selenite have carcinogenetic, cytotoxic and genotoxic effects. Therefore, removal of this toxic pullutant from the environment has a particular importance in maintaining public health. In this study, with the aim of optimization of selenite removal process, the design Box-Behnken method was used to estimate th...

the main objective of the present study is to investigate the feasibility of using carboxymethyl chitosan magnetic nanoparticles (ccmn) for the adsorption of cd2+. the study also reports important parameters, which affect the adsorption process, i.e., ph, adsorbent dose, contact time and concentration of cd2+, using box-behnken designs. firstly, functional carboxymethyl chitosan magnetic nanopa...