نتایج جستجو برای: boron neutron capture therapy
تعداد نتایج: 829590 فیلتر نتایج به سال:
This review compares the safety and efficacy of boron neutron capture therapy (BNCT) in the treatment of previously irradiated, inoperable locoregional recurrent HNC patients and compares BNCT against the standard treatment of platinum-based chemotherapy. Our analysis of published clinical trials highlights efficacy of BNCT associated with mild side effects. However, the use of BNCT should be e...
Background: Boron and gadolinium are among the nuclides that hold a unique property of being a neutron capture therapy agent. Neutron beams have often a considerable portion of gamma rays with fast neutrons. Gamma rays, as beam contaminants, can cause considerable damage to normal tissues even if such tissues do contain high boron concentrations. Materials and Methods: The modification of radio...
Boron neutron capture therapy (BNCT) is an effective method for treatment of deep seated brain tumors. This method consists of two stages: injection of boron compound in the patient body, and then irradiation of the region tumors with the neutron beam. It allows for delivery of high linear energy transfer (LET) radiation (particles 4He and 7Li nuclei) to tumors at the cellular level whilst avoi...
closo-Dodecaborate-encapsulating liposomes were developed as boron delivery vehicles for neutron capture therapy. The use of spermidinium as a counter cation of closo-dodecaborates was essential not only for the preparation of high boron content liposome solutions but also for efficient boron delivery to tumors.
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations were the most time consuming aspect of the treatment planning process, requiring more than thirty six...
*1102 Expression of Neural Cell Adhesion Molecule-related Sialoglycoprotein in Small Cell Lung Cancer and Neuroblastoma Cell Lines 1169 and CHP-212. C. E. C. Kitty Moolenaar. Egbert J. Muller, Dick J. Schol, Carl G. Figdor, Elizabeth Bock. Dieter Bitter-Suermann. and Rob J. A. M. Michalides. * 1107 Prolongation of Serum Half-Life of Interleukin 2 and Augmenta tion of Lymphokine-activated killer...
BACKGROUND Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid (ACBC)-BSH. ACBC is a tumor selective synthetic amino acid. The purpose of this study was to assess the biodistribution of ACBC-BSH an...
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